ArticleMolecular biology reports2009
ACE gene polymorphism and cardiac structure in patients with insulin resistance.
Article in Molecular biology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study.Journal of hypertension · 2010Trial
- Influences of the G2350A polymorphism in the ACE gene on cardiac structure and function of ball game players.Journal of negative results in biomedicine · 2012Article
- Significant association between insertion/deletion polymorphism of the angiotensin-convertig enzyme gene and ankylosing spondylitis.Molecular vision · 2012Article
- The therapeutic potential of G-CSF in pressure overload induced ventricular reconstruction and heart failure in mice.Molecular biology reports · 2012Article
- DD genotype of ace gene I/D polymorphism is associated in a Turkish study population with osteoarthritis.Molecular biology reports · 2011Article
- The frequency of factor V Leiden mutation, ACE gene polymorphism, serum ACE activity and response to ACE inhibitor and angiotensin II receptor antagonist drugs in Iranians type II diabetic patients with microalbuminuria.Molecular biology reports · 2011Article
- Angiotensin converting enzyme I/D, angiotensinogen M235T and AT1-R A/C1166 gene polymorphisms in patients with acromegaly.Molecular biology reports · 2011Article
- Implications of the angiotensin converting enzyme gene insertion/deletion polymorphism in health and disease: a snapshot review.International journal of molecular epidemiology and genetics · 2010Article
- An alternative method for genotyping of the ACE I/D polymorphism.Molecular biology reports · 2009Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAngiotensin-converting enzyme (ACE) is a key enzyme in the production of angiotensin II, thus may participate in the modulation of cardiac growth. The aim of our study is to analyze the ACE gene I/D polymorphisms in patients with insulin resistance (IR) and to evaluate its relationship to left ventricular mass and functions.
methodsEighteen subjects (13 female and 5 male, mean age 39.8 +/- 14) with IR were enrolled in the present study. Twenty-three healthy people without IR were recruited as the control group. ACE amplification of DNA was performed by polymerase chain reaction methodology. Fasting glucose and insulin, postprandial glucose, homeostasis model assessment (HOMA-IR) and HOMA-beta, lipid profile, anthropometric measurements were assessed. Left ventricular structure and functions were measured by echocardiography.
resultsDistribution of I/D polymorphism of the ACE gene in the study group was as follows: genotype II-0%, ID-38.9%, DD-61.1% of patients. Distribution of individual genotypes was similar in patients with and without IR. No significant difference was found between genotype groups in terms of anthropometric measurements and metabolic parameters and blood pressure. Echocardiography showed no significant changes in left ventricular structure and functions in patients with IR.
conclusionsWe considered that in patients with IR, there is no relationship between I/D polymorphism of the ACE gene and LVH.
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