ArticleAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2008
Perceived stress is associated with impaired T-cell response to HPV16 in women with cervical dysplasia.
Article in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Rapid Systematic Review-Informed Multidisciplinary Expert Consensus on the Management of HPV-Positive Women with Low-Grade Cervical Lesions and the Role of aMedicina (Kaunas, Lithuania) · 2026Pooled it
- Clinical Outcomes of a Multi-IngredientCancers · 2026Article
- Burden and risk factors of cervical cancer in Vietnam from 1990 to 2021 and forecasting to 2050-a systematic analysis from global burden disease.AJOG global reports · 2025Article
- Predictive models for personalized precision medical intervention in spontaneous regression stages of cervical precancerous lesions.Journal of translational medicine · 2024Article
- Emerging paradigms: unmasking the role of oxidative stress in HPV-induced carcinogenesis.Infectious agents and cancer · 2024Review
- Role of stress in the pathogenesis of cancer (Review).International journal of oncology · 2023Review
- Stress and cancer: mechanisms, significance and future directions.Nature reviews. Cancer · 2021Review
- Is stress related to the presence and persistence of oncogenic human papillomavirus infection in young women?BMC cancer · 2021Article
- The impact of intimate partner violence on breast and cervical cancer survivors in an integrated, safety-net setting.Journal of cancer survivorship : research and practice · 2020Article
- Human papilloma virus: Apprehending the link with carcinogenesis and unveiling new research avenues (Review).International journal of oncology · 2018Review
- HPV strain distribution in patients with genital warts in a female population sample.Oncology letters · 2016Article
- Bereavement Is Associated with an Increased Risk of HPV Infection and Cervical Cancer: An Epidemiological Study in Sweden.Cancer research · 2016Article
- Mindfulness-based stress reduction teachers, practice characteristics, cancer incidence, and health: a nationwide ecological description.BMC complementary and alternative medicine · 2015Article
- Acculturative stress and inflammation among Chinese immigrant women.Psychosomatic medicine · 2014Article
- Effect of stress and depression on the frequency of squamous intraepithelial lesions.Journal of lower genital tract disease · 2011Article
- Psychoneuroimmunology: Psychology's Gateway to the Biomedical Future.Perspectives on psychological science : a journal of the Association for Psychological Science · 2009Article
- Psychosocial factors in risk of cervical intraepithelial lesions.Journal of women's health (2002) · 2009Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundInfection with high-risk subtypes of human papillomavirus (HPV) is a central factor in the development of cervical neoplasia. Cell-mediated immunity against HPV16 plays an important role in the resolution of HPV infection and in controlling cervical disease progression. Research suggests that stress is associated with cervical disease progression, but few studies have examined the biological mechanisms that may be driving this association. PURPOSE: This study examines whether stress is associated with immune response to HPV16 among women with cervical dysplasia.
methodsSeventy-four women presenting for colposcopy completed measures of health behaviors, stressful life events and perceived stress. A blood sample was obtained to evaluate proliferative T-cell response to HPV16, and a cervical sample was obtained during gynecologic exam for HPV-typing.
resultsMore than 55% tested positive for one or more HPV subtypes. Women who did not show proliferative responses to HPV (i.e. non-responders) were more likely to be HPV(+) compared to women who had a response (i.e. responders). Consistent with study hypotheses, logistic regression revealed that higher levels of perceived stress were associated with a non-response to HPV16, controlling for relevant covariates. Stressful life events were not associated with T-cell response to HPV.
conclusionsHigher levels of perceived stress are associated with impaired HPV-specific immune response in women with cervical dysplasia, suggesting a potential mechanism by which stress may influence cervical disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.