ArticleCurrent genetics2008
Repeat induced point mutation in two asexual fungi, Aspergillus niger and Penicillium chrysogenum.
Article in Current genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- Chromosome-scale Genome Assembly of the Most Abundant Ectomycorrhizal Fungus Cenococcum Geophilum Reveals Massive TE Expansion and RIP Defense Mechanism.Genome biology and evolution · 2026Article
- De Novo Long-Read Whole-Genome Assemblies and the Comparative Pan-Genome Analysis of Ascochyta Blight Pathogens Affecting Field Pea.Journal of fungi (Basel, Switzerland) · 2022Article
- Review
- Population genomics reveals historical and ongoing recombination in theStudies in mycology · 2021Article
- Genome-Wide Analyses of Repeat-Induced Point Mutations in the Ascomycota.Frontiers in microbiology · 2020Article
- Article
- Repeat-Induced Point Mutations Drive Divergence betweenPathogens (Basel, Switzerland) · 2019Article
- Repeat elements organise 3D genome structure and mediate transcription in the filamentous fungus Epichloë festucae.PLoS genetics · 2018Article
- Genomic and Genetic Insights Into a Cosmopolitan Fungus,Frontiers in microbiology · 2018Article
- Comparative Genome Analysis Reveals Adaptation to the Ectophytic Lifestyle of Sooty Blotch and Flyspeck Fungi.Genome biology and evolution · 2017Article
- Sex and the Imperfect Fungi.Microbiology spectrum · 2017Review
- Article
- A Penicillium chrysogenum-based expression system for the production of small, cysteine-rich antifungal proteins for structural and functional analyses.Microbial cell factories · 2016Article
- Whole genome comparative analysis of transposable elements provides new insight into mechanisms of their inactivation in fungal genomes.BMC genomics · 2015Article
- Analysis of Tc1-Mariner elements in Sclerotinia sclerotiorum suggests recent activity and flexible transposases.BMC microbiology · 2014Article
- Characterization and potential evolutionary impact of transposable elements in the genome of Cochliobolus heterostrophus.BMC genomics · 2014Article
- Reverse transcriptase and intron number evolution.Stem cell investigation · 2014Article
- Multiple recent horizontal transfers of a large genomic region in cheese making fungi.Nature communications · 2014Article
- Sexual reproduction and mating-type-mediated strain development in the penicillin-producing fungus Penicillium chrysogenum.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Abundance, distribution and potential impact of transposable elements in the genome of Mycosphaerella fijiensis.BMC genomics · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Repeat induced point mutation (RIP) is a gene silencing mechanism present in fungal genomes. During RIP, duplicated sequences are efficiently and irreversibly mutated by transitions from C:G to T:A. For the first time, we have identified traces of RIP in transposable elements of Aspergillus niger and Penicillium chrysogenum, two biotechnologically relevant fungi. We found that RIP in P. chrysogenum has affected a large set of sequences, which also contain other mutations. On the other hand, RIP in A. niger is limited to only few sequences, but literally all mutations are RIP-like. Surprisingly, RIP occurred only in transposon sequences that have disrupted open reading frames in A. niger, a phenomenon not yet reported for other fungi. In both fungal species, we identified two sequences with strong sequence similarity to Neurospora crassa RID. RID is a putative DNA methyltransferase and the only known enzyme involved in the RIP process. Our findings suggest that both A. niger and P. chrysogenum either had a sexual past or have a sexual potential. These findings have important implications for future strain development of these fungi.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.