ArticleJournal of molecular evolution2008
Diversifying and purifying selection in the peptide binding region of DRB in mammals.
Article in Journal of molecular evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Sexual selection explains more functional variation in the mammalian major histocompatibility complex than parasitism.Proceedings. Biological sciences · 2013Pooled it
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- Partial molecular characterization, expression pattern and polymorphism analysis of MHC I genes in Chinese domestic goose (Anser cygnoides).Genetics and molecular biology · 2024Article
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- Using de novo genome assembly and high-throughput sequencing to characterize the MHC region in a non-model bird, the Eurasian coot.Scientific reports · 2022Article
- Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations.PLoS biology · 2019Article
- Low genetic variation in the MHC class II DRB gene and MHC-linked microsatellites in endangered island populations of the leopard cat (Prionailurus bengalensis) in Japan.Immunogenetics · 2018Article
- Adenine Enrichment at the Fourth CDS Residue in Bacterial Genes Is Consistent with Error Proofing for +1 Frameshifts.Molecular biology and evolution · 2017Article
- Characterization of MHC class I in a long distance migratory wader, the Icelandic black-tailed godwit.Immunogenetics · 2017Article
- Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection.Molecular biology and evolution · 2016Article
- Changes in variation at the MHC class II DQA locus during the final demise of the woolly mammoth.Scientific reports · 2016Article
- The Diversity and Molecular Evolution of B-Cell Receptors during Infection.Molecular biology and evolution · 2016Review
- Adaptive evolution of formyl peptide receptors in mammals.Journal of molecular evolution · 2015Article
- Positive selection on MHC class II DRB and DQB genes in the bank vole (Myodes glareolus).Journal of molecular evolution · 2014Article
- Evolution of MHC class I in the order Crocodylia.Immunogenetics · 2014Article
- Article
- Selection and trans-species polymorphism of major histocompatibility complex class II genes in the order Crocodylia.PloS one · 2014Article
- Duplication and population dynamics shape historic patterns of selection and genetic variation at the major histocompatibility complex in rodents.Ecology and evolution · 2013Article
- Evolution of major histocompatibility complex class I and class II genes in the brown bear.BMC evolutionary biology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The class II genes of the major histocompatibility complex encode proteins which play a crucial role in antigen presentation. They are among the most polymorphic proteins known, and this polymorphism is thought to be the result of natural selection. To understand the selective pressure acting on the protein and to examine possible differences in the evolutionary dynamics among species, we apply maximum likelihood models of codon substitution to analyze the DRB genes of six mammalian species: human, chimpanzee, macaque, tamarin, dog, and cow. The models account for variable selective pressures across codons in the gene and have the power to detect amino acid residues under either positive or negative selection. Our analysis detected positive selection in the DRB genes in each of the six mammals examined. Comparison with structural data reveals that almost all amino acid residues inferred to be under positive selection in humans are in the peptide binding region (PBR) and are in contact with the antigen side chains, although residues outside of but close to the PBR are also detected. Strong purifying selection is also detected in the PBR, at sites which contact the antigen and at sites which may be involved in dimerization or T cell binding. The analysis demonstrates the utility of the random-sites analysis even when structural information is available. The different mammalian species are found to share many positively or negatively selected sites, suggesting that their functional roles have remained very similar in the different species, despite the different habitats and pathogens of the species.
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