ArticleProceedings of the National Academy of Sciences of the United States of America2008
Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 83 citations in OpenAlex.
- Elevated SP-1 transcription factor expression and activity drives basal and hypoxia-induced vascular endothelial growth factor (VEGF) expression in non-small cell lung cancer.The Journal of biological chemistry · 2012Trial
- PGC-1s shape epidermal physiology by modulating keratinocyte proliferation and terminal differentiation.iScience · 2023Article
- Targeting Mitochondria to Control Ageing and Senescence.Pharmaceutics · 2023Review
- Adipocyte-Specific Expression of PGC1α Promotes Adipocyte Browning and Alleviates Obesity-Induced Metabolic Dysfunction in an HO-1-Dependent Fashion.Antioxidants (Basel, Switzerland) · 2022Article
- Preclinical evidence for mitochondrial DNA as a potential blood biomarker for chemotherapy-induced peripheral neuropathy.PloS one · 2022Article
- Article
- Posttranslational regulation of PGC-1α and its implication in cancer metabolism.International journal of cancer · 2019Review
- Mitochondrial regulator PGC-1a-Modulating the modulator.Current opinion in endocrine and metabolic research · 2019Article
- 5-HTAmerican journal of physiology. Renal physiology · 2018Article
- Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration.Molecular metabolism · 2018Article
- PGC1α in the kidney.American journal of physiology. Renal physiology · 2018Review
- Targeting hepatic glucose metabolism in the treatment of type 2 diabetes.Nature reviews. Drug discovery · 2016Review
- PGC-1 alpha regulates HO-1 expression, mitochondrial dynamics and biogenesis: Role of epoxyeicosatrienoic acid.Prostaglandins & other lipid mediators · 2016Article
- Article
- Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma.Cell reports · 2015Article
- Sinulolides A-H, new cyclopentenone and butenolide derivatives from soft coral Sinularia sp.Marine drugs · 2014Article
- Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization.BMC musculoskeletal disorders · 2014Article
- Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury.The Journal of pharmacology and experimental therapeutics · 2014Article
- Genetic models of PGC-1 and glucose metabolism and homeostasis.Reviews in endocrine & metabolic disorders · 2014Review
- A small-molecule inducer of PDX1 expression identified by high-throughput screening.Chemistry & biology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The transcriptional coactivator PGC-1alpha is a potent regulator of several metabolic pathways, including, in particular, the activation of oxidative phosphorylation and mitochondrial biogenesis. Recent evidence suggests that increasing PGC-1alpha activity may have beneficial effects in various conditions, including muscular dystrophy, diabetes, and neurodegenerative diseases. We describe here a high-throughput screen to identify small molecules that induce PGC-1alpha expression in skeletal muscle cells. A number of drug classes are identified, including glucocorticoids, microtubule inhibitors, and protein synthesis inhibitors. These drugs induce PGC-1alpha mRNA, and the expression of a number of genes known to be regulated by PGC-1alpha. No induction of these target genes is seen in PGC-1alpha -/- cells, demonstrating that the drugs act through PGC-1alpha. These data demonstrate the feasibility of high-throughput screening for inducers of PGC-1alpha. Moreover, the data identify microtubule inhibitors and protein synthesis inhibitors as modulators of PGC-1alpha and oxidative phosphorylation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.