ArticleAntimicrobial agents and chemotherapy2008
Susceptibility testing of anidulafungin and voriconazole alone and in combination against conidia and hyphae of Aspergillus spp. under hypoxic conditions.
Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
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Who cites it
15 citing papers in PubMed.
- Bronchopulmonary disposition of intravenous voriconazole and anidulafungin given in combination to healthy adults.Antimicrobial agents and chemotherapy · 2009Trial
- Review
- Effect of reduced oxygen on the antifungal susceptibility of clinically relevant aspergilli.Antimicrobial agents and chemotherapy · 2015Article
- Susceptibility profiles of amphotericin B and posaconazole against clinically relevant mucorales species under hypoxic conditions.Antimicrobial agents and chemotherapy · 2015Article
- In vitro interaction of voriconazole and anidulafungin against triazole-resistant Aspergillus fumigatus.Antimicrobial agents and chemotherapy · 2013Article
- Combination of voriconazole and anidulafungin for treatment of triazole-resistant aspergillus fumigatus in an in vitro model of invasive pulmonary aspergillosis.Antimicrobial agents and chemotherapy · 2012Article
- In vitro combination of anidulafungin and voriconazole against intrinsically azole-susceptible and -resistant Aspergillus spp.Antimicrobial agents and chemotherapy · 2012Article
- Hypoxia and fungal pathogenesis: to air or not to air?Eukaryotic cell · 2012Review
- Combined therapy of voriconazole and anidulafungin in murine infections by Aspergillus flavus.Mycopathologia · 2012Article
- Implications of hypoxic microenvironments during invasive aspergillosis.Medical mycology · 2011Review
- In Vitro Susceptibility Testing in Fungi: What is its Role in Clinical Practice?Current infectious disease reports · 2010Article
- Pharmacokinetics, antifungal activity and clinical efficacy of anidulafungin in the treatment of fungal infections.Expert opinion on drug metabolism & toxicology · 2010Review
- Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi?Medical mycology · 2010Review
- Combination therapy of advanced invasive pulmonary aspergillosis in transiently neutropenic rats using human pharmacokinetic equivalent doses of voriconazole and anidulafungin.Antimicrobial agents and chemotherapy · 2009Article
- A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus.PLoS pathogens · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MICs and fractional inhibitory concentrations were evaluated for anidulafungin and voriconazole alone and in combination against conidia and hyphae under hypoxic (1% oxygen-5% CO(2)-94% nitrogen) conditions against 31 Aspergillus isolates. Anidulafungin exhibited excellent activity against conidia and hyphae of Aspergillus spp. The visual reading of the MIC for anidulafungin was optimal under hypoxic conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.