ArticleInfection and immunity2008
EmaA, a potential virulence determinant of Aggregatibacter actinomycetemcomitans in infective endocarditis.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 65 citations in OpenAlex.
- The microbiome bone axis in osteomyelitis: integrating evidence from bone oral and gut microbiota.Microbiome research reports · 2026Review
- Microbiological and molecular aspects of periodontitis pathogenesis: an infection-induced inflammatory condition.Frontiers in cellular and infection microbiology · 2025Review
- From Global to Nano: A Geographical Perspective ofPathogens (Basel, Switzerland) · 2024Review
- The Trimeric Autotransporter Adhesin EmaA and Infective Endocarditis.Pathogens (Basel, Switzerland) · 2024Review
- Comparison of microbiota structure in reproductive tract of Yanbian cattle and Yanhuang cattle.Frontiers in microbiology · 2024Article
- Dual function of the O-antigen WaaL ligase of Aggregatibacter actinomycetemcomitans.Molecular oral microbiology · 2023Article
- Regulation of adhesin synthesis in Aggregatibacter actinomycetemcomitans.Molecular oral microbiology · 2023Article
- Persister Cell Formation and ElevatedMicroorganisms · 2023Article
- Human Serum Mediated Bacteriophage Life Cycle Switch inLife (Basel, Switzerland) · 2023Article
- Oral microbial interactions from an ecological perspective: a narrative review.Frontiers in oral health · 2023Review
- Serotype-Specific Sugars Impact Structure but Not Functions of the Trimeric Autotransporter Adhesin EmaA of Aggregatibacter actinomycetemcomitans.Journal of bacteriology · 2022Article
- The serotype a-EmaA adhesin ofMicrobiology (Reading, England) · 2022Article
- A Review of the Diversity of the Genital Tract Microbiome and Implications for Fertility of Cattle.Animals : an open access journal from MDPI · 2022Review
- Infective Endocarditis: A Focus on Oral Microbiota.Microorganisms · 2021Review
- Adhesion of anaerobic periodontal pathogens to extracellular matrix proteins.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Review
- Functional Analysis of the Collagen Binding Proteins of Streptococcus parasanguinis FW213.mSphere · 2020Article
- Herpesvirus-bacteria synergistic interaction in periodontitis.Periodontology 2000 · 2020Review
- Review
- Interactions between the Trimeric Autotransporter Adhesin EmaA and Collagen Revealed by Three-Dimensional Electron Tomography.Journal of bacteriology · 2019Article
- Tools ofJournal of clinical medicine · 2019Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The gram-negative fastidious human oropharyngeal Aggregatibacter actinomycetemcomitans is implicated in the etiology of infective endocarditis. EmaA, an oligomeric coiled-coil adhesin homologous to YadA of Yersinia enterocolitica, was hypothesized to mediate the interaction of A. actinomycetemcomitans with collagen. Collagen, the most abundant protein in human bodies and the main component of extracellular matrix (ECM), predominates in the supporting tissue of cardiac valves. To extend our earlier studies using purified collagen to determine bacterial binding activities, we developed a tissue model using rabbit cardiac valves to investigate the interaction of A. actinomycetemcomitans with native collagen. The resected mitral valves, with or without removal of the endothelium, were incubated with equivalent numbers of the wild type and the isogenic emaA mutant defective in collagen binding. There was no difference in binding between the wild-type and the mutant strains when the endothelium remained intact. However, the emaA mutant was fivefold less effective than the wild-type strain in colonizing the exposed ECM. A 10-fold increase in the binding of the wild-type strain to ECM was observed compared with the intact endothelium. Similar observations were replicated in an in vivo endocarditis rabbit model; the emaA mutant was 10-fold less effective in the initial infection of the traumatized aortic valve. Colocalization studies indicated that A. actinomycetemcomitans bound to type I collagen. A. actinomycetemcomitans preferentially colonized the ECM and, together with the evidence that EmaA interacts with the native collagen, suggested that the adhesin is likely a potential virulence determinant of the bacterium in the initiation of infective endocarditis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.