ArticleNucleic acids research2008
Autoregulation of the Escherichia coli melR promoter: repression involves four molecules of MelR.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- A Novel Dual-Applied and environmental microbiology · 2018Article
- Article
- Posttranscriptional self-regulation by the Lyme disease bacterium's BpuR DNA/RNA-binding protein.Journal of bacteriology · 2013Article
- Finely tuned regulation of the aromatic amine degradation pathway in Escherichia coli.Journal of bacteriology · 2013Article
- DNA looping in prokaryotes: experimental and theoretical approaches.Journal of bacteriology · 2013Review
- Negative effect of glucose on ompA mRNA stability: a potential role of cyclic AMP in the repression of hfq in Escherichia coli.Journal of bacteriology · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The Escherichia coli MelR protein is a transcription activator that autoregulates its own promoter by repressing transcription initiation. Optimal repression requires MelR binding to a site that overlaps the melR transcription start point and to upstream sites. In this work, we have investigated the different determinants needed for optimal repression and their spatial requirements. We show that repression requires a complex involving four DNA-bound MelR molecules, and that the global CRP regulator plays little or no role.
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Registered trials
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