ArticleJournal of muscle research and cell motility1991
Complex stiffness of smooth muscle cytoplasm in the presence of Ca-activated brevin.
Article in Journal of muscle research and cell motility, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- F-actin stabilization increases tension cost during contraction of permeabilized airway smooth muscle in dogs.The Journal of physiology · 1999Article
- X-ray diffraction study on mammalian visceral smooth muscles in resting and activated states.Journal of muscle research and cell motility · 1993Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
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Abstract
Brevin, an F-actin severing protein, regulates actin gel-sol transformation in a Ca(2+)-dependent way. Here, we tested its effect on the stiffness of the cytoplasm of skinned smooth muscle, in the absence of actin-myosin interaction (inhibited myosin ATPase). Complex stiffness was measured by imposing sinusoidal stretches and releases at different frequencies (1-50 Hz). In the presence of Ca-activated brevin, the stiffness decreased by about 30%, at all frequencies, from its initial values in Ca-free, relaxing solution. This decrease reflected a fall in both elasticity and viscosity of the cytoplasm. We propose that brevin specifically operates on an actin network in parallel with the contractile apparatus, e.g. on the actin-filamin gel.
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