ReviewSeminars in perinatology2008
Does abnormal bile acid metabolism contribute to NEC?
Review in Seminars in perinatology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Gut Microbiota-Derived Metabolites and Their Role in the Pathogenesis of Necrotizing Enterocolitis in Preterm Infants: A Narrative Review.Metabolites · 2024Review
- Article
- Deoxycholic acid aggravates necrotizing enterocolitis through downregulation of mesenchymal-epithelial transition factor expression.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024Article
- The inhibition of enterocyte proliferation by lithocholic acid exacerbates necrotizing enterocolitis through downregulating the Wnt/β-catenin signalling pathway.Cell proliferation · 2022Article
- Chorioamnionitis induces hepatic inflammation and time-dependent changes of the enterohepatic circulation in the ovine fetus.Scientific reports · 2021Article
- Review
- Human milk and infant formula differentially alters the microbiota composition and functional gene relative abundance in the small and large intestines in weanling rats.European journal of nutrition · 2020Article
- Article
- The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction?The Journal of pediatrics · 2017Review
- Protective effects of amniotic fluid in the setting of necrotizing enterocolitis.Pediatric research · 2017Review
- Fecal Bile Salts and the Development of Necrotizing Enterocolitis in Preterm Infants.PloS one · 2017Observational
- Necrotizing enterocolitis: new insights into pathogenesis and mechanisms.Nature reviews. Gastroenterology & hepatology · 2016Review
- Bile acids regulate intestinal cell proliferation by modulating EGFR and FXR signaling.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Toll-like receptor regulation of intestinal development and inflammation in the pathogenesis of necrotizing enterocolitis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2014Article
- The hepatic bile acid transporters Ntcp and Mrp2 are downregulated in experimental necrotizing enterocolitis.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Necrotizing enterocolitis risk: state of the science.Advances in neonatal care : official journal of the National Association of Neonatal Nurses · 2012Review
- Worms, flies and four-legged friends: the applicability of biological models to the understanding of intestinal inflammatory diseases.Disease models & mechanisms · 2011Review
- Active transport of bile acids decreases mucin 2 in neonatal ileum: implications for development of necrotizing enterocolitis.PloS one · 2011Article
- Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis.Seminars in liver disease · 2010Review
- OST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids.Frontiers in bioscience (Landmark edition) · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Bile acids (BAs) facilitate emulsification, absorption, and transport of fats and sterols in the intestine and liver and are essential for normal digestion. However, accumulation of BAs in the intestine can result in damage to the intestinal epithelium. Using the neonatal rat model of necrotizing enterocolitis (NEC), we have recently shown that BAs accumulate in both the ileal lumen and enterocytes of neonatal rats with NEC and the increased BA levels are positively correlated with disease severity. Importantly, when BAs are not allowed to accumulate, neonatal rat pups develop significantly less disease. In addition, BA transporters are altered during disease development. These data indicate that BAs play an important role in the development of experimental NEC, and suggest that the inability of neonatal rats to adequately regulate BA transporters may be a mechanism by which ileal damage occurs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.