ArticleBasic & clinical pharmacology & toxicology2008
Norsolorinic acid from Aspergillus nidulans inhibits the proliferation of human breast adenocarcinoma MCF-7 cells via Fas-mediated pathway.
Article in Basic & clinical pharmacology & toxicology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
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- Fungal Pigments and Their Prospects in Different Industries.Microorganisms · 2019Review
- Anthraquinones and Derivatives from Marine-Derived Fungi: Structural Diversity and Selected Biological Activities.Marine drugs · 2016Review
- Recent advances in genome mining of secondary metabolite biosynthetic gene clusters and the development of heterologous expression systems in Aspergillus nidulans.Journal of industrial microbiology & biotechnology · 2014Review
- Anticancer and antifungal compounds from Aspergillus, Penicillium and other filamentous fungi.Molecules (Basel, Switzerland) · 2013Review
- Genome-based cluster deletion reveals an endocrocin biosynthetic pathway in Aspergillus fumigatus.Applied and environmental microbiology · 2012Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Norsolorinic acid, isolated from the Aspergillus nidulans, was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. To identity the anticancer mechanism of norsolorinic acid, we assayed its effect on apoptosis, cell cycle distribution, and levels of p53, p21/WAF1, Fas/APO-1 receptor and Fas ligand. The results showed that norsolorinic acid induced apoptosis of MCF-7 cells without mediation of p53 and p21/WAF1. We suggest that Fas/Fas ligand apoptotic system is the main pathway of norsolorinic acid-mediated apoptosis of MCF-7 cells. Our study reports here for the first time that the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of norsolorinic acid in MCF-7 cells.
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