ArticleThe journal of headache and pain2008
The primary headaches: genetics, epigenetics and a behavioural genetic model.
Article in The journal of headache and pain, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Inflammation and histone modification in chronic pain.Frontiers in immunology · 2022Review
- Genomics and epigenomics.The journal of headache and pain · 2015Article
- Analytic information processing style in migraineurs.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Article
- Epigenetics and the transition from acute to chronic pain.Pain medicine (Malden, Mass.) · 2012Review
- Review
- Pain stress and headache.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2012Review
- Analytic cognitive style in cluster headache.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2011Article
- Genetic TPH2 variants and the susceptibility for migraine: association of a TPH2 haplotype with migraine without aura.Journal of neural transmission (Vienna, Austria : 1996) · 2010Article
- Tumour necrosis factor gene polymorphisms and migraine in Greek children.Archives of medical science : AMS · 2010Article
- Headache-type adverse effects of NO donors: vasodilation and beyond.British journal of pharmacology · 2010Review
- Lack of association between five serotonin metabolism-related genes and medication overuse headache.The journal of headache and pain · 2010Article
- [What is migraine?].Der Nervenarzt · 2009Review
- Molecular genetics of migraine.Human genetics · 2009Review
- Migraine: where and how does the pain originate?Experimental brain research · 2009Review
- Migraine as a visceral pain.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2009Review
- Serotonin and migraine: a reconsideration of the central theory.The journal of headache and pain · 2008Review
- Epigenetics and pharmaco-epigenetics in the primary headaches.The journal of headache and pain · 2008Article
- Epigenetics in primary headaches: a new avenue for research.The journal of headache and pain · 2008Article
- Migraine: a genetic disease?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2008Review
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1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The primary headaches, migraine with (MA) and without aura (MO) and cluster headache, all carry a substantial genetic liability. Familial hemiplegic migraine (FHM), an autosomal dominant mendelian disorder classified as a subtype of MA, is due to mutations in genes encoding neural channel subunits. MA/MO are considered multifactorial genetic disorders, and FHM has been proposed as a model for migraine aetiology. However, a review of the genetic studies suggests that the FHM genes are not involved in the typical migraines and that FHM should be considered as a syndromic migraine rather than a subtype of MA. Adopting the concept of syndromic migraine could be useful in understanding migraine pathogenesis. We hypothesise that epigenetic mechanisms play an important role in headache pathogenesis. A behavioural model is proposed, whereby the primary headaches are construed as behaviours, not symptoms, evolutionarily conserved for their adaptive value and engendered out of a genetic repertoire by a network of pattern generators present in the brain and signalling homeostatic imbalance. This behavioural model could be incorporated into migraine genetic research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.