ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2007
Nonalcoholic fatty pancreas disease.
Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 1 of them a synthesis that pooled it.
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Who cites it
92 citing papers in PubMed, 1 synthesis or guideline pooled it, 206 citations in OpenAlex.
- Body mass index and outcomes from pancreatic resection: a review and meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2011Pooled it
- Ethnic differences in pancreatic fat accumulation and its relationship with other fat depots and inflammatory markers.Diabetes care · 2011Trial
- Fatty pancreas: Current insights and future perspectives.World journal of methodology · 2026Review
- Development and validation of a clinical prediction model for fatty pancreas disease: from CT-based indicators to an easy-to-use prediction application.Nutrition journal · 2026Article
- Intrapancreatic fat deposition in the elderly: a retrospective cadaveric study with histopathological characterization.BMC gastroenterology · 2026Article
- Pancreatic steatosis is not associated with advanced steatohepatitis or fibrosis in metabolic dysfunction-associated steatotic liver disease.World journal of gastroenterology · 2025Article
- TNF as a mediator of metabolic inflammation and body-brain interaction in obesity-driven neuroinflammation and neurodegeneration.Ageing research reviews · 2025Review
- Retrospective study: analysis of risk factors and construction of prediction model for pancreatic steatosis.BMC gastroenterology · 2025Article
- Significance of Pancreatic Steatosis as a Predictor of New-Onset Diabetes Mellitus Following Pancreatectomy.Pancreas · 2025Article
- Vanishing pancreas: CT and MRI features and imaging diagnostic strategies.Insights into imaging · 2025Article
- Standardized pancreatic MRI-T1 measurement methods: comparison between manual measurement and a semi-automated pipeline with automatic quality control.The British journal of radiology · 2025Article
- Association of dietary glycemic index and glycemic load with pancreatic steatosis: a case control study.BMC endocrine disorders · 2025Article
- Effect of adipose tissue deposition on insulin resistance in middle-aged and elderly women: Based on QCT and MRI mDIXON-Quant.Journal of diabetes investigation · 2025Article
- Adherence to the dietary approaches to stop hypertension (DASH) and risk of pancreatic steatosis.Journal of health, population, and nutrition · 2024Article
- The gut-pancreas axis: investigating the relationship between microbiota metabolites and pancreatic steatosis.Internal and emergency medicine · 2024Article
- Computed tomography-based radiomics and body composition analysis for predicting clinically relevant postoperative pancreatic fistula after pancreaticoduodenectomy.Gland surgery · 2024Article
- Consumption of interesterified palm oil leads inflammation of white adipose tissue and triggers metabolic disturbances in mice on a high-fat diet.Scientific reports · 2024Article
- Does the Location of Fat Accumulation Affect the Degree of Aortic and Renal Arterial Calcification?Biomedicines · 2024Article
- Pancreatic Crosstalk in the Disease Setting: Understanding the Impact of Exocrine Disease on Endocrine Function.Comprehensive Physiology · 2024Review
- Pathophysiological Mechanisms and Clinical Associations of Non-Alcoholic Fatty Pancreas Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
32 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundObesity leads to fat infiltration of multiple organs including the heart, kidneys, and liver. Under conditions of oxidative stress, fat-derived cytokines are released locally and result in an inflammatory process and organ dysfunction. In the liver, fat infiltration has been termed nonalcoholic fatty liver disease, which may lead to nonalcoholic steatohepatitis. No data are available, however, on the influence of obesity on pancreatic fat and cytokines, and nonalcoholic fatty pancreas disease (NAFPD) has not been described. Therefore, we designed a study to determine whether obesity is associated with increased pancreatic fat and cytokines. MATERIALS AND
methodsThirty C57BL/6J lean control and 30 leptin-deficient obese female mice were fed a 15% fat diet for 4 weeks. At 12 weeks of age all animals underwent total pancreatectomy. Pancreata from each strain were pooled for measurement of a) wet and dry weight, b) histologic presence of fat, c) triglycerides, free fatty acids (FFAs), cholesterol, phospholipids, and total fat, and d) interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha). Data were analyzed by Student's t test and Fisher's exact test.
resultsPancreata from obese mice were heavier (p<0.05) and had more fat histologically (p<0.05). Pancreata from obese mice had more triglycerides, FFAs, cholesterol, and total fat (p<0.05). Triglycerides represented 11% of pancreatic fat in lean mice compared with 67% of pancreatic fat in obese mice (p<0.01). Cytokines IL-1beta and TNF-alpha also were elevated in the pancreata of obese mice (p<0.05).
conclusionsThese data suggest that obese mice have 1) heavier pancreata, 2) more pancreatic fat, especially triglycerides and FFAs, and 3) increased cytokines. We conclude that obesity leads to nonalcoholic fatty pancreatic disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.