ArticleEMBO reports2008
Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryos.
Article in EMBO reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 56 citations in OpenAlex.
- Evidence for the major role of PH4⍺EFB in the prolyl 4-hydroxylation of Drosophila collagen IV.Matrix biology : journal of the International Society for Matrix Biology · 2025Article
- Ferroptosis-like cell death promotes and prolongs inflammation in Drosophila.Nature cell biology · 2024Article
- Cellular and molecular mechanisms of skin wound healing.Nature reviews. Molecular cell biology · 2024Review
- The Development of New Methods to Stimulate the Production of Antimicrobial Peptides in the Larvae of the Black Soldier FlyInternational journal of molecular sciences · 2023Article
- Wound Healing Insights from Flies and Fish.Cold Spring Harbor perspectives in biology · 2022Review
- Intramacrophage ROS Primes the Innate Immune System via JAK/STAT and Toll Activation.Cell reports · 2020Article
- JNK signaling regulates oviposition in the malaria vector Anopheles gambiae.Scientific reports · 2020Article
- Comparative RNA-Seq analyses of Drosophila plasmatocytes reveal gene specific signatures in response to clean injury and septic injury.PloS one · 2020Article
- Injury Activates a Dynamic Cytoprotective Network to Confer Stress Resilience and Drive Repair.Current biology : CB · 2019Article
- Role ofGenes · 2019Article
- Requirement for and polarized localization of integrin proteins during Drosophila wound closure.Molecular biology of the cell · 2018Article
- Long-term In Vivo Tracking of Inflammatory Cell Dynamics Within Drosophila Pupae.Journal of visualized experiments : JoVE · 2018Article
- Interplay between trauma and Pseudomonas entomophila infection in flies: a central role of the JNK pathway and of CrebA.Scientific reports · 2017Article
- Review
- During Drosophila disc regeneration, JAK/STAT coordinates cell proliferation with Dilp8-mediated developmental delay.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Sterile inflammation in Drosophila.Mediators of inflammation · 2015Review
- Identification and functional analysis of healing regulators in Drosophila.PLoS genetics · 2015Article
- Do the genes of the innate immune response contribute to neuroprotection in Drosophila?Journal of innate immunity · 2015Review
- Cyclin-dependent kinase 8 module expression profiling reveals requirement of mediator subunits 12 and 13 for transcription of Serpent-dependent innate immunity genes in Drosophila.The Journal of biological chemistry · 2014Article
- Ecdysone mediates the development of immunity in the Drosophila embryo.Current biology : CB · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
By using a microarray screen to compare gene responses after sterile laser wounding of wild-type and 'macrophageless' serpent mutant Drosophila embryos, we show the wound-induced programmes that are independent of a pathogenic response and distinguish which of the genes are macrophage dependent. The evolutionarily conserved nature of this response is highlighted by our finding that one such new inflammation-associated gene, growth arrest and DNA damage-inducible gene 45 (GADD45), is upregulated in both Drosophila and murine repair models. Comparison of unwounded wild-type and serpent mutant embryos also shows a portfolio of 'macrophage-specific' genes, which suggest analogous functions with vertebrate inflammatory cells. Besides identifying the various classes of wound- and macrophage-related genes, our data indicate that sterile injury per se, in the absence of pathogens, triggers induction of a 'pathogen response', which might prime the organism for what is likely to be an increased risk of infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.