Trial reportGenetics in medicine : official journal of the American College of Medical Genetics2008
Incorporating ethnicity into genetic risk assessment for Alzheimer disease: the REVEAL study experience.
Trial report in Genetics in medicine : official journal of the American College of Medical Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical implications of APOE genotyping for late-onset Alzheimer's disease (LOAD) risk estimation: a review of the literature.Journal of neural transmission (Vienna, Austria : 1996) · 2019Pooled it
- Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors.Genetics in medicine : official journal of the American College of Medical Genetics · 2011Guideline
- A randomized controlled trial of disclosing genetic risk information for Alzheimer disease via telephone.Genetics in medicine : official journal of the American College of Medical Genetics · 2018Trial
- Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial.Annals of internal medicine · 2016Trial
- A randomized noninferiority trial of condensed protocols for genetic risk disclosure of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Trial
- Factors affecting recall of different types of personal genetic information about Alzheimer's disease risk: the REVEAL study.Public health genomics · 2015Trial
- Effectiveness of a condensed protocol for disclosing APOE genotype and providing risk education for Alzheimer disease.Genetics in medicine : official journal of the American College of Medical Genetics · 2012Trial
- "I know what you told me, but this is what I think:" perceived risk of Alzheimer disease among individuals who accurately recall their genetics-based risk estimate.Genetics in medicine : official journal of the American College of Medical Genetics · 2010Trial
- Patient and provider perspectives on polygenic risk scores: implications for clinical reporting and utilization.Genome medicine · 2022Article
- Polygenic risk scores in the clinic: new perspectives needed on familiar ethical issues.Genome medicine · 2021Article
- The association between hypertension and other cardiovascular risk factors among non-diabetic Saudis adults-A cross sectional study.PloS one · 2021Article
- Assessing the Psychological Impact of Genetic Susceptibility Testing.The Hastings Center report · 2019Article
- Physicians' perspectives on receiving unsolicited genomic results.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- "Well, good luck with that": reactions to learning of increased genetic risk for Alzheimer disease.Genetics in medicine : official journal of the American College of Medical Genetics · 2018Article
- Evaluation of a Web-based decision aid for people considering the APOE genetic test for Alzheimer risk.Genetics in medicine : official journal of the American College of Medical Genetics · 2017Article
- A Hierarchical Feature and Sample Selection Framework and Its Application for Alzheimer's Disease Diagnosis.Scientific reports · 2017Article
- APOE Genotype in the Ethnic Majority and Minority Groups of Laos and the Implications for Non-Communicable Diseases.PloS one · 2016Article
- Associations between self-referral and health behavior responses to genetic risk information.Genome medicine · 2015Article
- The Alzheimer's Prevention Clinic at Weill Cornell Medical College / New York - Presbyterian Hospital: Risk Stratification and Personalized Early Intervention.The journal of prevention of Alzheimer's disease · 2015Article
- Distinct communication patterns during genetic counseling for late-onset Alzheimer's risk assessment.Patient education and counseling · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
purposeTo describe how investigators in a multisite randomized clinical trial addressed scientific and ethical issues involved in creating risk models based on genetic testing for African American participants.
methodsThe following informed our decision whether to stratify risk assessment by ethnicity: evaluation of epidemiological data, appraisal of benefits and risks of incorporating ethnicity into calculations, and feasibility of creating ethnicity-specific risk curves. Once the decision was made, risk curves were created based on data from a large, diverse study of first-degree relatives of patients with Alzheimer disease.
resultsReview of epidemiological data suggested notable differences in risk between African Americans and whites and that Apolipoprotein E genotype predicts risk in both groups. Discussions about the benefits and risks of stratified risk assessments reached consensus that estimates based on data from whites should not preclude enrolling African Americans, but population-specific risk curves should be created if feasible. Risk models specific to ethnicity, gender, and Apolipoprotein E genotype were subsequently developed for the randomized clinical trial that oversampled African Americans.
conclusionThe Risk Evaluation and Education for Alzheimer Disease study provides an instructive example of a process to develop risk assessment protocols that are sensitive to the implications of genetic testing for multiple ethnic groups with differing levels of risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.