ArticleApplied and environmental microbiology2008
Isolation and identification of rhizoxin analogs from Pseudomonas fluorescens Pf-5 by using a genomic mining strategy.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 115 citations in OpenAlex.
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- Relation of pest insect-killing and soilborne pathogen-inhibition abilities to species diversification in environmental Pseudomonas protegens.The ISME journal · 2023Article
- Polyyne-producingFrontiers in microbiology · 2023Article
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- Bacterial-fungal interactions under agricultural settings: from physical to chemical interactions.Stress biology · 2022Review
- Pyoluteorin and 2,4-diacetylphloroglucinol are major contributors toFrontiers in microbiology · 2022Article
- Delving into defence: identifying theMicrobial genomics · 2021Article
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- Pseudomonas species isolated via high-throughput screening significantly protect cotton plants against verticillium wilt.AMB Express · 2020Article
- Taxonomy and Phylogenetic Research on Ralstonia solanacearum Species Complex: A Complex Pathogen with Extraordinary Economic Consequences.Pathogens (Basel, Switzerland) · 2020Review
- Ring-Closing Metathesis Approaches towards the Total Synthesis of Rhizoxins.Molecules (Basel, Switzerland) · 2020Article
- Draft Genome Sequence ofMicrobiology resource announcements · 2020Article
- Draft Genome Sequence of Pseudomonas chlororaphis subsp.Microbiology resource announcements · 2020Article
- Engineering Pseudomonas protegens Pf-5 to improve its antifungal activity and nitrogen fixation.Microbial biotechnology · 2020Article
- Genetic factors involved in rhizosphere colonization by phytobeneficialComputational and structural biotechnology journal · 2020Review
- Discovery of an Antibiotic-Related Small Protein of Biocontrol StrainFrontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The products synthesized from a hybrid polyketide synthase/nonribosomal peptide synthetase gene cluster in the genome of Pseudomonas fluorescens Pf-5 were identified using a genomics-guided strategy involving insertional mutagenesis and subsequent metabolite profiling. Five analogs of rhizoxin, a 16-member macrolide with antifungal, phytotoxic, and antitumor activities, were produced by Pf-5, but not by a mutant with an insertion in the gene cluster. The five rhizoxin analogs, one of which had not been described previously, were differentially toxic to two agriculturally important plant pathogens, Botrytis cinerea and Phytophthora ramorum. The rhizoxin analogs also caused swelling of rice roots, a symptom characteristic of rhizoxin itself, but were less toxic to pea and cucumber roots. Of the rhizoxin analogs produced by Pf-5, the predominant compound, WF-1360 F, and the newly described compound 22Z-WF-1360 F were most toxic against the two plant pathogens and three plant species. These rhizoxin analogs were tested against a panel of human cancer lines, and they exhibited potent but nonselective cytotoxicity. This study highlights the value of the genomic sequence of the soil bacterium P. fluorescens Pf-5 in providing leads for the discovery of novel metabolites with significant biological properties.
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