ArticleNeurochemical research2008
Guanidinoacetate decreases antioxidant defenses and total protein sulfhydryl content in striatum of rats.
Article in Neurochemical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- Creatine metabolism and safety profiles after six-week oral guanidinoacetic acid administration in healthy humans.International journal of medical sciences · 2013Trial
- Review
- Safety of Dietary Guanidinoacetic Acid: A Villain of a Good Guy?Nutrients · 2021Review
- Current status of surviving patients with arginase 1 deficiency in Japan.Molecular genetics and metabolism reports · 2021Article
- Regulative Mechanism of Guanidinoacetic Acid on Skeletal Muscle Development and Its Application Prospects in Animal Husbandry: A Review.Frontiers in nutrition · 2021Review
- Age-Dependent Decline in Cardiac Function in Guanidinoacetate-Frontiers in physiology · 2019Article
- Growth Performance and Right Ventricular Hypertrophy Responses of Broiler Chickens to Guanidinoacetic Acid Supplementation under Hypobaric Hypoxia.The journal of poultry science · 2018Article
- Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency.Journal of inherited metabolic disease · 2016Article
- Advanced physiological roles of guanidinoacetic acid.European journal of nutrition · 2015Review
- Oxidative stress parameters of Gaucher disease type I patients.Molecular genetics and metabolism reports · 2015Article
- Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart.PloS one · 2014Article
- Effect of chronic administration of the vinyl chalcogenide 3-methyl-1-phenyl-2-(phenylseleno)oct-2-en-1-one on oxidative stress in different brain areas of rats.Neurochemical research · 2012Article
- Effect of acute administration of 3-butyl-1-phenyl-2-(phenyltelluro)oct-en-1-one on oxidative stress in cerebral cortex, hippocampus, and cerebellum of rats.Cellular and molecular neurobiology · 2010Article
- Creatine prevents the inhibition of energy metabolism and lipid peroxidation in rats subjected to GAA administration.Metabolic brain disease · 2010Article
- Effect of in vitro exposure of human serum to 3-butyl-1-phenyl-2-(phenyltelluro)oct-en-1-one on oxidative stress.Molecular and cellular biochemistry · 2009Article
- Oxidative stress in the hippocampus during experimental seizures can be ameliorated with the antioxidant ascorbic acid.Oxidative medicine and cellular longevityArticle
- Acute seizure activity promotes lipid peroxidation, increased nitrite levels and adaptive pathways against oxidative stress in the frontal cortex and striatum.Oxidative medicine and cellular longevityArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Guanidinoacetate methyltransferase (GAMT) deficiency is an inherited neurometabolic disorder biochemically characterized by tissue accumulation of guanidinoacetate (GAA) and depletion of creatine. Affected patients present epilepsy and mental retardation whose pathogeny is unclear. In the present study we investigated the in vitro and in vivo (intrastriatal administration) effects of GAA on some oxidative stress parameters in rat striatum. Sixty-day-old rats were used for intrastriatal infusion of GAA. For the in vitro studies, 60-day-old Wistar rats were killed by decapitation and the striatum was pre-incubated for 1 h at 37 degrees C in the presence of GAA at final concentrations ranging from 10 to 100 microM. Parameters of oxidative stress such as total radical-trapping antioxidant potential (TRAP), antioxidant enzymes (SOD, GPx, and CAT), protein carbonyl and thiol contents were measured. DNA damage was also evaluated. Results showed that GAA administration (in vivo studies) or the addition of 100 microM GAA to assays (in vitro studies) significantly decreased TRAP, SOD activity, and total thiol levels in rat striatum. In contrast, this guanidino compound did not alter protein carbonyl content and the activities of CAT and GPx. DNA damage was not found after intrastriatal administration of GAA. The data indicate that the metabolite accumulating in GAMT deficiency decreases antioxidant capacity and total thiol content in the striatum. It is therefore presumed that this pathomechanism may contribute at least in part to the pathophysiology of the brain injury observed in patients affected by GAMT deficiency.
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