ArticleVirus genes2008
Phylogenetic analysis of porcine circovirus type 2 (PCV2) pre- and post-epizootic postweaning multisystemic wasting syndrome (PMWS).
Article in Virus genes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Efficacy Studies against PCV-2 of a New Trivalent Vaccine including PCV-2a and PCV-2b Genotypes andVaccines · 2022Article
- Survey of porcine circovirus type 2 and parvovirus in swine breeding herds of Colombia.Veterinary medicine and science · 2022Article
- Multiplex polymerase chain reaction for the detection and differentiation of 4 porcine circovirus 2 genotypes (PCV-2a, -2b, -2d, and -2e) in clinical samples.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2022Article
- Genotyping of Porcine Circovirus 2 (PCV-2) in Vaccinated Pigs Suffering from PCV-2-Systemic Disease between 2009 and 2020 in Spain.Pathogens (Basel, Switzerland) · 2021Article
- Porcine Circovirus 2 Genotypes, Immunity and Vaccines: Multiple Genotypes but One Single Serotype.Pathogens (Basel, Switzerland) · 2020Review
- Genetic diversity and different cross-neutralization capability of porcine circovirus type 2 isolates recently circulating in South Korea.BMC veterinary research · 2020Article
- Changes on the viral capsid surface during the evolution of porcine circovirus type 2 (PCV2) from 2009 till 2018 may lead to a better receptor binding.Virus evolution · 2019Article
- Structural roles of PCV2 capsid protein N-terminus in PCV2 particle assembly and identification of PCV2 type-specific neutralizing epitope.PLoS pathogens · 2019Article
- Regulation of Apoptosis During Porcine Circovirus Type 2 Infection.Frontiers in microbiology · 2018Review
- Porcine circovirus 2 (PCV-2) genotype update and proposal of a new genotyping methodology.PloS one · 2018Article
- Viral Metagenomic Analysis Displays the Co-Infection Situation in Healthy and PMWS Affected Pigs.PloS one · 2016Article
- Revisiting the taxonomical classification of Porcine Circovirus type 2 (PCV2): still a real challenge.Virology journal · 2015Article
- Complete Genome Sequence of Porcine Circovirus Type 2 Strain HB-MC1.Genome announcements · 2014Article
- Detection and molecular characterization of porcine circovirus type 2 from piglets with porcine circovirus associated diseases in Colombia.Virology journal · 2014Article
- Porcine circovirus type 2 in China: an update on and insights to its prevalence and control.Virology journal · 2014Review
- Pigs naturally exposed to porcine circovirus type 2 (PCV2) generate antibody responses capable to neutralise PCV2 isolates of different genotypes and geographic origins.Veterinary research · 2014Article
- Development of an in situ assay for simultaneous detection of the genomic and replicative form of PCV2 using padlock probes and rolling circle amplification.Virology journal · 2011Article
- Cytotoxicity of ORF3 proteins from a nonpathogenic and a pathogenic porcine circovirus.Journal of virology · 2010Article
- Dynamics of serum antibodies to and load of porcine circovirus type 2 (PCV2) in pigs in three finishing herds, affected or not by postweaning multisystemic wasting syndrome.Acta veterinaria Scandinavica · 2010Article
- The index herd with PMWS in Sweden: presence of serum amyloid A, circovirus 2 viral load and antibody levels in healthy and PMWS-affected pigs.Acta veterinaria Scandinavica · 2009Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
The porcine circovirus type 2 (PCV2) genome encodes three major open reading frames (ORFs) encoding the replicase proteins (ORF1), the viral capsid protein (ORF2), and a protein with suggested apoptotic activity (ORF3). Previous phylogenetic analyses of complete genome sequences of PCV2 from GenBank have demonstrated 95-100% intra-group nucleotide sequence identity. However, although these isolates were readily grouped into clusters and clades, there was no correlation between the occurrence of specific PCV2 genotypes and the geographic origin or health status of the pig. In the present study, a unique dataset from a field study spanning the years pre and post the recognition of postweaning multisystemic wasting syndrome (PMWS) in Sweden was utilized. Using this dataset it was possible to discriminate three Swedish genogroups (SG1-3) of PCV2, of which SG1 was recovered from a pig on a healthy farm ten years before the first diagnosis of PMWS in Sweden. The SG1 PCV2/ORF2 gene sequence has been demonstrated to exhibit a high genetic stability over time and has subsequently only been demonstrated in samples from pigs on nondiseased farms. In contrast, SG2 was almost exclusively found on farms that had only recently broken down with PMWS whereas the SG3 genogroup predominated in pigs from PMWS-affected farms. These results further support the results obtained from earlier in vitro and in vivo experimental models and suggest the association of specific PCV2 genogroups with diseased and nondiseased pigs in the field.
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