ArticlePflugers Archiv : European journal of physiology2008
Effects of phorbol ester on vesicle dynamics as revealed by total internal reflection fluorescence microscopy.
Article in Pflugers Archiv : European journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- A two-subpopulation model that reflects heterogeneity of large dense core vesicles in exocytosis.Cell cycle (Georgetown, Tex.) · 2022Article
- Fingolimod--a sphingosine-like molecule inhibits vesicle mobility and secretion in astrocytes.Glia · 2012Article
- PKC epsilon facilitates recovery of exocytosis after an exhausting stimulation.Pflugers Archiv : European journal of physiology · 2009Article
- Roles of cholesterol in vesicle fusion and motion.Biophysical journal · 2009Article
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Authors and funding
4 authors.
Funding
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Abstract
Exocytosis of neurotransmitter or hormone-filled vesicles is a highly dynamic process regulated by various proteins and lipids. As mainly revealed indirectly by the electrophysiological methods, exocytosis is believed to involve multiple kinetic steps in which vesicles transit from one state to another. Using total internal reflection fluorescence microscopy which enables direct visualization of individual vesicles, we developed an analytical framework to track and analyze vesicle dynamics. We demonstrated that all subplasmalemmal vesicles generally undergo constant and caged Brownian motion. And they can be classified into three populations that differ in their motion characteristics and fusion competence. Furthermore, we showed that these vesicle pools are differentially modulated by phorbol-12-myristate-13-acetate, a phorbol ester analog to endogenous diacylglycerol, through both protein-kinase-C-dependent and -independent pathways.
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Registered trials
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