ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2008
Visualization of growth signal transduction cascades in living cells with genetically encoded probes based on Förster resonance energy transfer.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The multifaceted significance of phosphoinositides in endocytic trafficking.FEBS letters · 2026Review
- Tracking the Dynamic Histone Methylation of H3K27 in Live Cancer Cells.ACS sensors · 2021Article
- Single-Molecular Förster Resonance Energy Transfer Measurement on Structures and Interactions of Biomolecules.Micromachines · 2021Review
- Automated Fluorescence Lifetime Imaging High-Content Analysis of Förster Resonance Energy Transfer between Endogenously Labeled Kinetochore Proteins in Live Budding Yeast Cells.SLAS technology · 2019Article
- SensorFRET: A Standardless Approach to Measuring Pixel-based Spectral Bleed-through and FRET Efficiency using Spectral Imaging.Scientific reports · 2017Article
- Noninvasive Imaging of Ras Activity by Monomolecular Biosensor Based on Split-Luciferase Complementary Assay.Scientific reports · 2017Article
- Open Source High Content Analysis Utilizing Automated Fluorescence Lifetime Imaging Microscopy.Journal of visualized experiments : JoVE · 2017Article
- Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.Scientific reports · 2017Article
- Novel Bioluminescent Activatable Reporter for Src Tyrosine Kinase Activity in Living Mice.Theranostics · 2016Article
- Quantitative analysis of recombination between YFP and CFP genes of FRET biosensors introduced by lentiviral or retroviral gene transfer.Scientific reports · 2015Article
- Toward understanding RhoGTPase specificity: structure, function and local activation.Small GTPases · 2014Review
- Role of PTEN in modulation of ADP-dependent signaling pathways in vascular endothelial cells.Biochimica et biophysica acta · 2013Article
- Probing enzymatic activity inside living cells using a nanowire-cell "sandwich" assay.Nano letters · 2013Article
- Novel split-luciferase-based genetically encoded biosensors for noninvasive visualization of Rho GTPases.PloS one · 2013Article
- Angiotensin-II and MARCKS: a hydrogen peroxide- and RAC1-dependent signaling pathway in vascular endothelium.The Journal of biological chemistry · 2012Article
- Optogenetic reporters: Fluorescent protein-based genetically encoded indicators of signaling and metabolism in the brain.Progress in brain research · 2012Review
- Systematic control of protein interactions for systems biology.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Development of an optimized backbone of FRET biosensors for kinases and GTPases.Molecular biology of the cell · 2011Article
- The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf.The Journal of biological chemistry · 2010Article
- Measuring and interpreting the selectivity of protein kinase inhibitors.Journal of chemical biology · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluorescence probes based on the principle of Förster resonance energy transfer (FRET) have shed new light on our understanding of signal transduction cascades. Among them, unimolecular FRET probes containing fluorescence proteins are rapidly increasing in number because these genetically encoded probes can be easily loaded into living cells and allow simple acquisition of FRET images. We have developed probes for small GTPases, tyrosine kinases, serine-threonine kinases and phosphoinositides. Images obtained with these probes have revealed that membrane protrusions such as nascent lamellipodia or neurites provide an active signalling platform in the growth factor-stimulated cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.