ArticleGenomics2008
Alterations in myocardial gene expression associated with experimental Trypanosoma cruzi infection.
Article in Genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Pooled it
- Cardiac alterations induced by Trypanosoma cruzi extracellular vesicles and immune complexes.PLoS neglected tropical diseases · 2025Article
- Transcriptional Studies onFrontiers in cellular and infection microbiology · 2021Review
- EarlyFrontiers in microbiology · 2018Article
- AKT network of genes and impaired myocardial contractility during murine acute Chagasic myocarditis.The American journal of tropical medicine and hygiene · 2015Article
- Bone marrow-derived cell therapy in chagasic cardiac disease: a review of pre-clinical and clinical results.Cardiovascular diagnosis and therapy · 2012Review
- Microarray analysis of the mammalian thromboxane receptor-Trypanosoma cruzi interaction.Cell cycle (Georgetown, Tex.) · 2011Article
- Gap junctions and chagas disease.Advances in parasitology · 2011Review
- Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy.The Journal of infectious diseases · 2010Article
- Gene network analysis during early infection of human coronary artery smooth muscle cells by Trypanosoma cruzi and Its gp83 ligand.Chemistry & biodiversity · 2010Article
- Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi.The American journal of tropical medicine and hygiene · 2010Article
- Transcriptomic alterations in Trypanosoma cruzi-infected cardiac myocytes.Microbes and infection · 2009Article
- Micro-positron emission tomography in the evaluation of Trypanosoma cruzi-induced heart disease: Comparison with other modalities.The American journal of tropical medicine and hygiene · 2009Article
- Perspectives on the Trypanosoma cruzi-host cell receptor interactions.Parasitology research · 2009Review
- Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease).Progress in cardiovascular diseasesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
Abstract
Chagas disease, characterized by acute myocarditis and chronic cardiomyopathy, is caused by infection with the protozoan parasite Trypanosoma cruzi. We sought to identify genes altered during the development of parasite-induced cardiomyopathy. Microarrays containing 27,400 sequence-verified mouse cDNAs were used to analyze global gene expression changes in the myocardium of a murine model of chagasic cardiomyopathy. Changes in gene expression were determined as the acute stage of infection developed into the chronic stage. This analysis was performed on the hearts of male CD-1 mice infected with trypomastigotes of T. cruzi (Brazil strain). At each interval we compared infected and uninfected mice and confirmed the microarray data with dye reversal. We identified eight distinct categories of mRNAs that were differentially regulated during infection and identified dysregulation of several key genes. These data may provide insight into the pathogenesis of chagasic cardiomyopathy and provide new targets for intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.