ArticleCytokine2008
Mitogen activated protein kinase (MAPK) mediates non-genomic pathway of estrogen on T cell cytokine production following trauma-hemorrhage.
Article in Cytokine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Sex hormones and gender differences in immune responses and anticancer immunity: a comprehensive review.Biologia futura · 2026Review
- Mechanisms of Immune Tolerance and Inflammation via Gonadal Steroid Hormones in Preterm Birth.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2023Article
- TClinical and translational medicine · 2021Article
- Estradiol-induced inhibition of endoplasmic reticulum stress normalizes splenic CD4 + T lymphocytes following hemorrhagic shock.Scientific reports · 2021Article
- Neuroimmunomodulation by estrogen in health and disease.AIMS neuroscience · 2020Review
- Article
- Oxyresveratrol Is a Phytoestrogen Exerting Anti-inflammatory Effects Through NF-κB and Estrogen Receptor Signaling.Inflammation · 2017Article
- Sex differences in immune responses.Nature reviews. Immunology · 2016Review
- Enhanced generation of suppressor T cells in patients with asthma taking oral contraceptives.The Journal of asthma : official journal of the Association for the Care of Asthma · 2013Article
- Consequences of nongenomic actions of estradiol on pathogenic genital tract response.Journal of molecular signaling · 2013Article
- Estrogen modulates the influence of cardiac inflammatory cells on function of cardiac fibroblasts.Journal of inflammation research · 2013Article
- Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis.Hormones and behavior · 2012Review
- Vascular effects of phytoestrogens and alternative menopausal hormone therapy in cardiovascular disease.Mini reviews in medicinal chemistry · 2012Review
- Puerarin suppresses proliferation of endometriotic stromal cells partly via the MAPK signaling pathway induced by 17ß-estradiol-BSA.PloS one · 2012Article
- Salutary effects of 17beta-estradiol on Peyer's patch T cell functions following trauma-hemorrhage.Cytokine · 2010Article
- Estrogen augments the T cell-dependent but not the T-independent immune response.Cellular and molecular life sciences : CMLS · 2010Article
- KLF6 inhibits estrogen receptor-mediated cell growth in breast cancer via a c-Src-mediated pathway.Molecular and cellular biochemistry · 2010Article
- Regulation of estrogen receptor beta activity and implications in health and disease.Cellular and molecular life sciences : CMLS · 2009Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Although studies have shown 17beta-estradiol (E2) administration following trauma-hemorrhage (T-H) attenuates alterations in T cell cytokine production, it remains unknown whether such effects of E2 are mediated via genomic or non-genomic pathways. In this study, we determined the non-genomic effects of E2 on splenic T cell cytokine production and the role of MAPK following T-H. Male Sprague-Dawley rats underwent T-H (mean BP 40 mmHg for 90 min, then resuscitation). E2, E2 conjugated with BSA (E2-BSA, 1 mg/kg E2) with or without an estrogen receptor antagonist (ICI 182 780), or vehicle was administered during resuscitation. Two hours thereafter, T cell production of IL-2 and IFN-gamma and activation of MAPK (p38, ERK-1/2 and JNK) were determined. The effect of selective MAPK inhibitors on cytokine production was also examined in vitro. IL-2 and IFN-gamma production capacity and MAPK activation decreased in T cells following T-H. However, E2 administration normalized these parameters. Although E2-BSA administration also attenuated suppression in cytokine production, the values were lower compared to sham. In contrast, E2-BSA prevented T-H-induced suppression in MAPK activation to the same extent as E2. Co-administration of ICI 182 780 abolished E2-BSA effects. These findings suggest E2 effects on T cell cytokine production following T-H are mediated at least in part via non-genomic pathway and these non-genomic effects are likely mediated via MAPK pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.