Evidence map›Paper›PMID 18343032›Full record

ArticleNeuroscience letters2008

Contribution of P2Y(1) receptors to ADP signalling in mouse spinal cord cultures.

Amelia E Atterbury-Thomas, Catherine Leon, Christian Gachet, Ian D Forsythe, Richard J Evans

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Amelia E Atterbury-ThomasDepartment of Cell Physiology & Pharmacology, Henry Wellcome Building, University of Leicester, Leicester LE1 9HN, UK.
Catherine Leon
Christian Gachet
Ian D Forsythe
Richard J Evans
University of Leicester · GBÉtablissement Français du Sang · FRInserm · FR

Funding

Medical Research Council MC_U132681855Wellcome Trust
6 · The paper itself

Abstract

Mixed neuronal and glial cell spinal cord cultures from neonates express ADP sensitive P2Y(1,12&13) receptors. ADP (10microM) evoked increases in intracellular calcium that were essentially abolished by the P2Y(1) receptor antagonist MRS2179 (10microM), responses were also absent in preparations from P2Y(1) receptor deficient mice however UTP (100microM) evoked calcium rises were unaffected. ADP also evoked a robust increase in extracellular signal-regulated protein kinase (ERK) phosphorylation that was of similar magnitude in the cultures from wild type and P2Y(1) receptor deficient mice. These results suggest that ADP acts through P2Y(1) receptors to mediate an increase in intracellular calcium but not to stimulate ERK phosphorylation in the spinal cord.

Indexed as

Adenosine DiphosphateAniline CompoundsAnimalsCalciumDose-Response Relationship, DrugDrug InteractionsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutPurinergic P2 Receptor AntagonistsReceptors, Purinergic P2Receptors, Purinergic P2Y1Signal TransductionSpinal CordAdenosine DiphosphateAniline CompoundsCalciumFluo-3N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphateP2ry1 protein, mousePurinergic P2 Receptor AntagonistsReceptors, Purinergic P2Receptors, Purinergic P2Y1Uridine TriphosphateXanthenes

Identifiers

PMID18343032
PMCPMC2330064
OpenAlexW1983695638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.