ArticleExperimental eye research2008
Lens diameter and thickness as a function of age and pharmacologically stimulated accommodation in rhesus monkeys.
Article in Experimental eye research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Pseudomyopia and cycloplegic changes in young cynomolgus macaques.Molecular vision · 2025Article
- Effects of accommodation on geometrical parameters of human lens: A systematic review and meta-analysis.Heliyon · 2024Article
- The evolution of mechanism of accommodation and a novel hypothesis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Review
- Age-Related Differences in Ocular Features of a Naturalistic Free-Ranging Population of Rhesus Macaques.Investigative ophthalmology & visual science · 2023Article
- Improvement in Accommodation and Dynamic Range of Focus After Laser Scleral Microporation: A Potential Treatment for Presbyopia.Translational vision science & technology · 2022Article
- Age- and sex-related differences in the measures of anterior segment parameters in a myopic clinical sample using Pentacam Scheimpflug tomography.International ophthalmology · 2022Article
- Age-related changes of lens thickness and density in different age phases.International journal of ophthalmology · 2022Article
- Normative Data of Ocular Biometry, Optical Coherence Tomography, and Electrophysiology Conducted for Cynomolgus Macaque Monkeys.Translational vision science & technology · 2021Article
- Age-related changes in the rhesus macaque eye.Experimental eye research · 2021Article
- Age-Related Changes of the Human Crystalline Lens on High-Spatial Resolution Three-Dimensional T1-Weighted Brain Magnetic Resonance Images In Vivo.Investigative ophthalmology & visual science · 2020Article
- Anterior chamber indices in a population-based study using the Pentacam.International ophthalmology · 2019Article
- Translational Preclinical Pharmacologic Disease Models for Ophthalmic Drug Development.Pharmaceutical research · 2019Review
- Optical Coherence Tomography Reveals Sigmoidal Crystalline Lens Changes during Accommodation.Vision (Basel, Switzerland) · 2018Article
- Evaluating relaxed ciliary muscle tone in presbyopic eyes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2017Observational
- The effect of pupil dilation on AL-Scan biometric parameters.International ophthalmology · 2016Article
- Nonhuman Primate Ocular Biometry.Investigative ophthalmology & visual science · 2016Article
- Spectral sensitivity differences between rhesus monkeys and humans: implications for neurophysiology.Journal of neurophysiology · 2014Article
- Pharmacologically stimulated pupil and accommodative changes in Guinea pigs.Investigative ophthalmology & visual science · 2014Article
- Influence of shape and gradient refractive index in the accommodative changes of spherical aberration in nonhuman primate crystalline lenses.Investigative ophthalmology & visual science · 2013Article
- Extralenticular and lenticular aspects of accommodation and presbyopia in human versus monkey eyes.Investigative ophthalmology & visual science · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Uncertainty exists regarding accommodative and age changes in lens diameter and thickness in humans and monkeys. In this study, unaccommodated and accommodated refraction, lens diameter, and lens thickness were measured in rhesus monkeys across a range of ages. Iridectomized eyes were studied in 33 anesthetized monkeys aged 4-23 years. Refraction was measured using a Hartinger coincidence refractometer and lens thickness was measured with A-scan ultrasound. Lens diameters were measured with image analysis from slit-lamp images captured via a video camera while a saline filled, plano perfusion lens was placed on the cornea. Accommodation was pharmacologically stimulated with 2% pilocarpine via the perfusion lens in 21 of the monkeys and lens diameters were measured until a stable minimum was achieved. Refraction and lens thickness were measured again after the eye was accommodated. Unaccommodated lens thickness increased linearly with age by 0.029 mm/year while unaccommodated lens diameter showed no systematic change with age. Accommodative amplitude decreased by 0.462 D/year in response to pilocarpine. The accommodative increase in lens thickness decreased with age by 0.022 mm/year. The accommodative decrease in lens diameter declined linearly with age by 0.021 mm/year. Rhesus monkeys undergo the expected presbyopic changes including increasing lens thickness and a decreasing ability of the lens to undergo changes in thickness and diameter with accommodation, however without an age-related change in unaccommodated lens diameter. As in humans, the age-related decrease in accommodative amplitude in rhesus monkeys cannot be attributed to an age-related increase in lens diameter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.