ArticleJournal of the American College of Cardiology2008
Prolonged signal-averaged P-wave duration as an intermediate phenotype for familial atrial fibrillation.
Article in Journal of the American College of Cardiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Discovery ofBiology · 2023Article
- A novel PRRX1 loss-of-function variation contributing to familial atrial fibrillation and congenital patent ductus arteriosus.Genetics and molecular biology · 2022Article
- P-wave signal-averaged electrocardiography: Reference values, clinical correlates, and heritability in the Framingham Heart Study.Heart rhythm · 2021Observational
- The molecular genetic basis of atrial fibrillation.Human genetics · 2020Review
- Assessing Atrial Fibrillation Substrates by P Wave Analysis: A Comprehensive Review.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2020Review
- The Genetic Puzzle of Familial Atrial Fibrillation.Frontiers in cardiovascular medicine · 2020Review
- Atrial Fibrillation andCardiac electrophysiology clinics · 2014Article
- Whole-exome sequencing in familial atrial fibrillation.European heart journal · 2014Article
- Number of P-wave fragmentations on P-SAECG correlates with infiltrated atrial fat.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2014Article
- Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation.Journal of the American College of Cardiology · 2012Article
- Genetics of atrial fibrillation and possible implications for ischemic stroke.Stroke research and treatment · 2011Article
- Validation of an atrial fibrillation risk algorithm in whites and African Americans.Archives of internal medicine · 2010Article
- Novel KCNA5 mutation implicates tyrosine kinase signaling in human atrial fibrillation.Heart rhythm · 2010Article
- Association study of TRPC4 as a candidate gene for generalized epilepsy with photosensitivity.Neuromolecular medicine · 2010Article
- P wave indices: current status and future directions in epidemiology, clinical, and research applications.Circulation. Arrhythmia and electrophysiology · 2009Review
- Arrhythmia pharmacogenomics: methodological considerations.Current pharmaceutical design · 2009Review
- Cardiac sodium channel variants: action players with many faces.Heart rhythm · 2008Article
- Article
- Association of blood pressure and aortic distensibility with P wave indices and PR interval: the multi-ethnic study of atherosclerosis (MESA).Journal of electrocardiologyArticle
- Lone AF - Etiologic Factors and Genetic Insights into Pathophysiolgy.Journal of atrial fibrillationReview
Corrections and comments
- Commented on by
Authors and funding
4 authors.
Funding
Abstract
objectivesThis study sought to perform a genome-wide linkage analysis in a large atrial fibrillation (AF) kindred using AF and abnormally prolonged signal-averaged (SA) P-wave duration as the phenotype.
backgroundAlthough inherited forms of AF exist, phenotypic complexity has limited efforts to ascertain mutation carriers and thus identify causal genes. The identification of intermediate or endophenotypes may accelerate this effort.
methodsA genome-wide linkage analysis was performed in a 4-generation AF kindred of 27 individuals, 8 with AF documented by electrocardiogram. The analysis was performed using AF as the phenotype, and repeated using an abnormally prolonged SA P-wave duration as the phenotype.
resultsLinkage analysis and fine mapping generated a maximum multipoint logarithm of the odds (LOD) score of 3.0 at chromosome 5p15 between markers D5S406 and D5S635. Importantly, 8 heterozygous carriers had a prolonged SA P-wave (203 +/- 21 ms) compared with 17 noncarriers (116 +/- 12 ms, p < 0.00001). Using prolonged SA P-wave (conventionally defined as >155 ms) as an endophenotype, a maximum LOD score of 3.6 was obtained in the same region of chromosome 5p15, a span of 5.75 centi-Morgans.
conclusionsIn a large AF kindred, we have identified a novel AF locus on chromosome 5p15 and shown that affected individuals with AF and mutation carriers can be identified by a prolonged SA P-wave duration. Importantly, identification of an endophenotype in this kindred not only aided ascertainment of additional family members but also increased the LOD score, providing increased support for linkage at this locus. Identification of the causal gene, mapped to chromosome 5p15, will advance our understanding of the molecular basis of AF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.