ArticleEuropean journal of applied physiology2008
Effects of concentric and repeated eccentric exercise on muscle damage and calpain-calpastatin gene expression in human skeletal muscle.
Article in European journal of applied physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Minimal Evidence for a Secondary Loss of Strength After an Acute Muscle Injury: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2017Pooled it
- Trial
- Improved recovery from skeletal muscle damage is largely unexplained by myofibrillar protein synthesis or inflammatory and regenerative gene expression pathways.American journal of physiology. Endocrinology and metabolism · 2021Trial
- Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions.Physiological reviews · 2023Review
- Changes in Skeletal Muscle Troponin T and Vitamin D Binding Protein (DBP) Concentrations in the Blood of Male Amateur Athletes Participating in a Marathon and 100 km Adventure Race.International journal of environmental research and public health · 2023Article
- Article
- Does Obesity Affect the Severity of Exercise-Induced Muscle Injury?Journal of obesity & metabolic syndrome · 2021Review
- Can Exercise-Induced Muscle Damage Be a Good Model for the Investigation of the Anti-Inflammatory Properties of Diet in Humans?Biomedicines · 2021Review
- Changes in Urinary Titin N-terminal Fragment Concentration after Concentric and Eccentric Exercise.Journal of sports science & medicine · 2020Article
- Contralateral Effects by Unilateral Eccentric versus Concentric Resistance Training.Medicine and science in sports and exercise · 2020Article
- Comparison among three different intensities of eccentric contractions of the elbow flexors resulting in the same strength loss at one day post-exercise for changes in indirect muscle damage markers.European journal of applied physiology · 2020Article
- Metabolic Profiling of Eccentric Exercise-Induced Muscle Damage in Human Urine.Toxicological research · 2018Article
- Changes in central and peripheral neuromuscular fatigue indices after concentric versus eccentric contractions of the knee extensors.European journal of applied physiology · 2018Article
- Past injurious exercise attenuates activation of primary calcium-dependent injury pathways in skeletal muscle during subsequent exercise.Physiological reports · 2018Article
- The effect of different acute muscle contraction regimens on the expression of muscle proteolytic signaling proteins and genes.Physiological reports · 2017Article
- Eccentric Exercise, Kinesiology Tape, and Balance in Healthy Men.Journal of athletic training · 2017Article
- Muscle damage and repeated bout effect following blood flow restricted exercise.European journal of applied physiology · 2016Article
- Repeated bouts of fast velocity eccentric contractions induce atrophy of gastrocnemius muscle in rats.Journal of muscle research and cell motility · 2015Article
- Changes in foot volume, body composition, and hydration status in male and female 24-hour ultra-mountain bikers.Journal of the International Society of Sports Nutrition · 2014Article
- Strength gain through eccentric isotonic training without changes in clinical signs or blood markers.BMC musculoskeletal disorders · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to compare the responsiveness of changes in Ca(2+)-content and calpain-calpastatin gene expression to concentric and eccentric single-bout and repeated exercise. An exercise group (n = 14) performed two bouts of bench-stepping exercise with 8 weeks between exercise bouts, and was compared to a control-group (n = 6). Muscle strength and soreness and plasma creatine kinase and myoglobin were measured before and during 7 days following exercise bouts. Muscle biopsies were collected from m. vastus lateralis of both legs prior to and at 3, 24 h and 7 days after exercise and quantified for muscle Ca(2+)-content and mRNA levels for calpain isoforms and calpastatin. Exercise reduced muscle strength and increased muscle soreness predominantly in the eccentric leg (P < 0.05). These responses as well as plasma levels of creatine kinase and myoglobin were all attenuated after the repeated eccentric exercise bout (P < 0.05). Total muscle Ca(2+)-content did not differ between interventions. mRNA levels for calpain 2 and calpastatin were upregulated exclusively by eccentric exercise 24 h post-exercise (P < 0.05), with no alteration in expression between bouts. Calpain 1 and calpain 3 mRNA did not change at any specific time point post-exercise for either intervention. Our mRNA results suggest a regulation on the calpain-calpastatin expression response to muscle damaging eccentric exercise, but not concentric exercise. Although a repeated bout effect was demonstrated in terms of muscle function, no immediate support was provided to suggest that regulation of expression of specific system components is involved in the repeated bout adaptation.
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Registered trials
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