Evidence map›Paper›PMID 18340344›Full record

ReviewNature reviews. Immunology2008

Evolutionary struggles between NK cells and viruses.

Lewis L Lanier

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 261 papers.

0numbers the graph read from it
0cells of the map it votes in
261citing papers in PubMed
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

261 citing papers in PubMed, 445 citations in OpenAlex.

  1. Article
  2. Infection and immunity · 2026
    Review
  3. Review
  4. Mapping CMV-related immune signatures in blood, aorta and perivascular mediastinal adipose tissue.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Assessment of the risk of unexplained recurrent spontaneous abortion based on the proportion and correlation of NK cells and T cells in peripheral blood.Technology and health care : official journal of the European Society for Engineering and Medicine · 2023
    Article
  19. Article
  20. A family of unusual immunoglobulin superfamily genes in an invertebrate histocompatibility complex.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article

201 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Lewis L LanierDepartment of Microbiology and Immunology, and the Cancer Research Institute, University of California San Francisco, San Francisco, California 94143-0414, USA. lewis.lanier@ucsf.edu
Cancer Research Institute · US

Funding

NK Cells and HIV InfectionP01AI064520 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRODSKY, FRANCES M. · 2005 to 2009
$6.2M
NK MemoryR01AI068129 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANIER, LEWIS LEE · 2006 to 2020
$6.0M
NK and T Cell Costimulation by NKG2D/DAP10R37AI066897 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANIER, LEWIS LEE · 2006 to 2015
$3.8M
RAE-1 Family of Proteins in Innate and Adaptive ImmunityR01CA095137 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANIER, LEWIS LEE · 2003 to 2013
$2.9M
NCI NIH HHS R01 CA095137NIAID NIH HHS P01 AI064520NIAID NIH HHS R01 AI068129NIAID NIH HHS R37 AI066897
6 · The paper itself

Abstract

Natural killer (NK) cells are well recognized for their ability to provide a first line of defence against viral pathogens and they are increasingly being implicated in immune responses against certain bacterial and parasitic infections. Reciprocally, viruses have devised numerous strategies to evade the activation of NK cells and have influenced the evolution of NK-cell receptors and their ligands. NK cells contribute to host defence by their ability to rapidly secrete cytokines and chemokines, as well as to directly kill infected host cells. In addition to their participation in the immediate innate immune response against infection, interactions between NK cells and dendritic cells shape the nature of the subsequent adaptive immune response to pathogens.

Indexed as

Cytotoxicity, ImmunologicAnimalsDendritic CellsHumansKiller Cells, NaturalViruses

Identifiers

PMID18340344
PMCPMC2584366
OpenAlexW2011017810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.