ArticleGenome research2008
Genomic evolution of the placenta using co-option and duplication and divergence.
Article in Genome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
62 citing papers in PubMed.
- Extensive load of somatic CNVs in the human placenta.Scientific reports · 2015Trial
- Differences in gene expression between first and third trimester human placenta: a microarray study.PloS one · 2012Trial
- Cross-species insights into placental evolution and diseases at the single-cell resolution.Nature communications · 2026Article
- Co-option of the trichome-forming network initiated the evolution of a morphological novelty in Drosophila eugracilis.Current biology : CB · 2024Article
- Single-cell analysis of the amphioxus hepatic caecum and vertebrate liver reveals genetic mechanisms of vertebrate liver evolution.Nature ecology & evolution · 2024Article
- Article
- Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor.eLife · 2023Article
- Adaptive structural and functional evolution of the placenta protects fetal growth in high-elevation deer mice.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Gestationally dependent immune organization at the maternal-fetal interface.Cell reports · 2022Article
- Here and there a trophoblast, a transcriptional evaluation of trophoblast cell models.Cellular and molecular life sciences : CMLS · 2022Review
- Mammalian tumor-like organs. 1. The role of tumor-like normal organs and atypical tumor organs in the evolution of development (carcino-evo-devo).Infectious agents and cancer · 2022Review
- Mapping cis-regulatory elements in the midgestation mouse placenta.Scientific reports · 2021Article
- Placental secretome characterization identifies candidates for pregnancy complications.Communications biology · 2021Article
- Examining Sex Differences in the Human Placental Transcriptome During the First Fetal Androgen Peak.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- The Genomes of the Livebearing Fish Species Poeciliopsis retropinna and Poeciliopsis turrubarensis Reflect Their Different Reproductive Strategies.Molecular biology and evolution · 2020Article
- Baby Genomics: Tracing the Evolutionary Changes That Gave Rise to Placentation.Genome biology and evolution · 2020Article
- Article
- Placental programming of neuropsychiatric disease.Pediatric research · 2019Review
- De novo characterization of placental transcriptome in the Eurasian beaver (Castor fiber L.).Functional & integrative genomics · 2019Article
- Cholecystokinin, gastrin, cholecystokinin/gastrin receptors, and bitter taste receptor TAS2R14: trophoblast expression and signaling.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The invention of the placenta facilitated the evolution of mammals. How the placenta evolved from the simple structure observed in birds and reptiles into the complex organ that sustains human life is one of the great mysteries of evolution. By using a timecourse microarray analysis including the entire lifetime of the placenta, we uncover molecular and genomic changes that underlie placentation and find that two distinct evolutionary mechanisms were utilized during placental evolution in mice and human. Ancient genes involved in growth and metabolism were co-opted for use during early embryogenesis, likely enabling the accelerated development of extraembryonic tissues. Recently duplicated genes are utilized at later stages of placentation to meet the metabolic needs of a diverse range of pregnancy physiologies. Together, these mechanisms served to develop the specialized placenta, a novel structure that led to expansion of the eutherian mammal, including humankind.
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Registered trials
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