ArticleProceedings of the National Academy of Sciences of the United States of America2008
Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 79 citations in OpenAlex.
- Active and Unusually Expanded PIF/Harbinger Transposable Elements in the Caenorhabditis inopinata Genome.Genome biology and evolution · 2026Article
- Evolutionary innovation through fusion of sequences from across the tree of life.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Harboring Starships: The Accumulation of Large Horizontal Gene Transfers in Domesticated and Pathogenic Fungi.Genome biology and evolution · 2025Article
- The Fire Ant Social Chromosome Exerts a Major Influence on Genome Regulation.Molecular biology and evolution · 2025Article
- High-Throughput Discovery of Substrate Peptide Sequences for E3 Ubiquitin Ligases Using a cDNA Display Method.Chembiochem : a European journal of chemical biology · 2024Article
- Extreme-Phenotype Genome-Wide Association Analysis for Growth Traits in Spotted Sea Bass (Animals : an open access journal from MDPI · 2024Article
- Harbinger transposon insertion in ethylene signaling gene leads to emergence of new sexual forms in cucurbits.Nature communications · 2024Article
- Expression of OsHARBI1-1 enhances the tolerance of Arabidopsis thaliana to cadmium.BMC plant biology · 2023Article
- Mobility of mPing and its associated elements is regulated by both internal and terminal sequences.Mobile DNA · 2023Article
- Transposase expression, element abundance, element size, and DNA repair determine the mobility and heritability ofFrontiers in cell and developmental biology · 2023Article
- Recurrent co-domestication of PIF/Harbinger transposable element proteins in insects.Mobile DNA · 2022Article
- The neurodevelopmental gene MSANTD2 belongs to a gene family formed by recurrent molecular domestication of Harbinger transposons at the base of vertebrates.Molecular biology and evolution · 2022Article
- Diversity ofAnimals : an open access journal from MDPI · 2022Article
- Schizophrenia-Linked Protein tSNARE1 Regulates Endosomal Trafficking in Cortical Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Assessing the Impact of a Viral Infection on the Expression of Transposable Elements in the Cabbage Looper Moth (Trichoplusia ni).Genome biology and evolution · 2021Article
- Review
- MAD1L1 and TSNARE gene polymorphisms are associated with schizophrenia susceptibility in the Han Chinese population.BMC medical genomics · 2021Article
- Horizontal transfer and subsequent explosive expansion of a DNA transposon in sea kraits (Biology letters · 2021Article
- Contemporary Transposon Tools: A Review and Guide through Mechanisms and Applications ofInternational journal of molecular sciences · 2021Review
- Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ancient, inactive copies of transposable elements of the PIF/Harbinger superfamily have been described in vertebrates. We reconstructed components of the Harbinger3_DR transposon in zebrafish, including a transposase and a second, transposon-encoded protein that has a Myb-like trihelix domain. The reconstructed Harbinger transposon shows efficient cut-and-paste transposition in human cells and preferentially inserts into a 15-bp consensus target sequence. The Myb-like protein is required for transposition and physically interacts with the N-terminal region of the transposase via its C-terminal domain. The Myb-like protein enables transposition in part by promoting nuclear import of the transposase, by directly binding to subterminal regions of the transposon, and by recruiting the transposase to the transposon ends. We investigated the functions of two transposon-derived human proteins: HARBI1, a domesticated transposase-derived protein, and NAIF1, which contains a trihelix motif similar to that described in the Myb-like protein. Physical interaction, subcellular localization, and DNA-binding activities of HARBI1 and NAIF1 suggest strong functional homologies between the Harbinger3_DR system and their related, host-encoded counterparts. The Harbinger transposon will serve as a useful experimental system for transposon biology and for investigating the enzymatic functions of domesticated, transposon-derived cellular genes.
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