ArticleBiophysical journal2008
A biophysically based mathematical model of unitary potential activity in interstitial cells of Cajal.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- ER morphological analysis associated with interstitial cells of Cajal and smooth muscle cells in the murine stomach.Cell and tissue research · 2025Article
- CaPhysiological reviews · 2024Review
- Computational models of autonomic regulation in gastric motility: Progress, challenges, and future directions.Frontiers in neuroscience · 2023Review
- Current applications of mathematical models of the interstitial cells of Cajal in the gastrointestinal tract.WIREs mechanisms of disease · 2021Review
- A quantitative systems pharmacology model of colonic motility with applications in drug development.Journal of pharmacokinetics and pharmacodynamics · 2019Article
- Computational motility models of neurogastroenterology and neuromodulation.Brain research · 2018Review
- A biophysically detailed computational model of urinary bladder small DRG neuron soma.PLoS computational biology · 2018Article
- The effects of mitochondrial inhibitors on CaCell calcium · 2018Article
- Original Research: Combined model of bladder detrusor smooth muscle and interstitial cells.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Interstitial cells: regulators of smooth muscle function.Physiological reviews · 2014Review
- Mitochondrial calcium handling within the interstitial cells of Cajal.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Targeting ion channels for the treatment of gastrointestinal motility disorders.Therapeutic advances in gastroenterology · 2012Article
- Biophysically based modeling of the interstitial cells of cajal: current status and future perspectives.Frontiers in physiology · 2011Article
- Article
- Tissue-specific mathematical models of slow wave entrainment in wild-type and 5-HT(2B) knockout mice with altered interstitial cells of Cajal networks.Biophysical journal · 2010Article
- Multiscale modeling of gastrointestinal electrophysiology and experimental validation.Critical reviews in biomedical engineering · 2010Review
- A tissue framework for simulating the effects of gastric electrical stimulation and in vivo validation.IEEE transactions on bio-medical engineering · 2009Article
- A Ca(2+)-activated Cl(-) conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity.The Journal of physiology · 2009Article
- Biophysically based mathematical modeling of interstitial cells of Cajal slow wave activity generated from a discrete unitary potential basis.Biophysical journal · 2009Article
- Toward the virtual stomach: progress in multiscale modeling of gastric electrophysiology and motility.Wiley interdisciplinary reviews. Systems biology and medicineReview
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Unitary potential (UP) depolarizations are the basic intracellular events responsible for pacemaker activity in interstitial cells of Cajal (ICCs), and are generated at intracellular sites termed "pacemaker units". In this study, we present a mathematical model of the transmembrane ion flows and intracellular Ca(2+) dynamics from a single ICC pacemaker unit acting at near-resting membrane potential. This model quantitatively formalizes the framework of a novel ICC pacemaking mechanism that has recently been proposed. Model simulations produce spontaneously rhythmic UP depolarizations with an amplitude of approximately 3 mV at a frequency of 0.05 Hz. The model predicts that the main inward currents, carried by a Ca(2+)-inhibited nonselective cation conductance, are activated by depletion of sub-plasma-membrane [Ca(2+)] caused by sarcoendoplasmic reticulum calcium ATPase Ca(2+) sequestration. Furthermore, pacemaker activity predicted by our model persists under simulated voltage clamp and is independent of [IP(3)] oscillations. The model presented here provides a basis to quantitatively analyze UP depolarizations and the biophysical mechanisms underlying their production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.