ArticleEndocrinology2008
Paired-like homeodomain transcription factors 1 and 2 regulate follicle-stimulating hormone beta-subunit transcription through a conserved cis-element.
Article in Endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Whole-genome de novo sequencing reveals genomic variants associated with differences of sex development in SRY negative pigs.Biology of sex differences · 2024Article
- Distal Enhancer Potentiates Activin- and GnRH-Induced Transcription of FSHB.Endocrinology · 2021Article
- FSHB Transcription is Regulated by a Novel 5' Distal Enhancer With a Fertility-Associated Single Nucleotide Polymorphism.Endocrinology · 2021Article
- PACAP induces FSHβ gene expression via EPAC.Molecular and cellular endocrinology · 2019Article
- Molecular regulation of follicle-stimulating hormone synthesis, secretion and action.Journal of molecular endocrinology · 2018Review
- Regulatory Architecture of the LβT2 Gonadotrope Cell Underlying the Response to Gonadotropin-Releasing Hormone.Frontiers in endocrinology · 2018Article
- Long-chain unsaturated fatty acids reduce the transcriptional activity of the rat follicle-stimulating hormone β-subunit gene.The Journal of reproduction and development · 2016Article
- Minireview: Activin Signaling in Gonadotropes: What Does the FOX say… to the SMAD?Molecular endocrinology (Baltimore, Md.) · 2015Review
- Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Follicle-stimulating hormone synthesis and fertility are intact in mice lacking SMAD3 DNA binding activity and SMAD2 in gonadotrope cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Forkhead box O1 is a repressor of basal and GnRH-induced Fshb transcription in gonadotropes.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice.Molecular endocrinology (Baltimore, Md.) · 2013Article
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- Article
- SMADs and FOXL2 synergistically regulate murine FSHbeta transcription via a conserved proximal promoter element.Molecular endocrinology (Baltimore, Md.) · 2011Article
- MIP/Aquaporin 0 represents a direct transcriptional target of PITX3 in the developing lens.PloS one · 2011Article
- A FoxL in the Smad house: activin regulation of FSH.Trends in endocrinology and metabolism: TEM · 2010Review
- Pin1 facilitates the phosphorylation-dependent ubiquitination of SF-1 to regulate gonadotropin beta-subunit gene transcription.Molecular and cellular biology · 2010Article
- A novel role for the forkhead transcription factor FOXL2 in activin A-regulated follicle-stimulating hormone beta subunit transcription.Molecular endocrinology (Baltimore, Md.) · 2009Article
- The biology of activin: recent advances in structure, regulation and function.The Journal of endocrinology · 2009Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Paired-like homeodomain transcription factors (PITX) regulate the activity of pituitary hormone-encoding genes. Here, we examined mechanisms through which the family of PITX proteins control murine FSH beta-subunit (Fshb) transcription. We observed that endogenous PITX1 and PITX2 isoforms from murine LbetaT2 gonadotrope cells could bind a highly conserved proximal cis-element. Transfection of PITX1 or PITX2C in heterologous cells stimulated both murine and human Fshb/FSHB promoter-reporter activities, and in both cases, mutation of the critical cis-element abrogated these effects. In homologous LbetaT2 cells, the same mutation decreased basal reporter activity and greatly reduced activin A-stimulated transcription from murine and human promoter-reporters. Transfecting dominant-negative forms of PITX1 or PITX2C or knocking down PITX1 or -2 expression by RNA interference in LbetaT2 cells inhibited murine Fshb transcription, confirming roles for endogenous PITX proteins. Both PITX1 and PITX2C interacted with Smad3 (an effector of the activin signaling cascade in these cells) in coprecipitation experiments, and the PITX binding site mutation greatly inhibited Smad2/3/4-stimulated Fshb transcription. In summary, both PITX1 and PITX2C regulate murine and human Fshb/FSHB transcription through a conserved cis-element in the proximal promoter. Furthermore, the data indicate both common and distinct mechanisms of PITX1 and PITX2C action.
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Registered trials
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