ArticleThe Journal of physiology2008
Involvement of AMPA receptor desensitization in short-term synaptic depression at the calyx of Held in developing rats.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short-term plasticity.The Journal of physiology · 2025Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Plasticity in Cervical Motor Circuits following Spinal Cord Injury and Rehabilitation.Biology · 2021Review
- Frequency-Dependent Block of Excitatory Neurotransmission by Isoflurane via Dual Presynaptic Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Timing constraints of action potential evoked CaScientific reports · 2019Article
- EGTA Can Inhibit Vesicular Release in the Nanodomain of Single CaFrontiers in synaptic neuroscience · 2019Article
- Enhanced Transmission at the Calyx of Held Synapse in a Mouse Model for Angelman Syndrome.Frontiers in cellular neuroscience · 2017Article
- Review on the role of AMPA receptor nano-organization and dynamic in the properties of synaptic transmission.Neurophotonics · 2016Review
- The calyx of Held in the auditory system: Structure, function, and development.Hearing research · 2016Review
- Acoustic trauma slows AMPA receptor-mediated EPSCs in the auditory brainstem, reducing GluA4 subunit expression as a mechanism to rescue binaural function.The Journal of physiology · 2016Article
- Reconstitution of Giant Mammalian Synapses in Culture for Molecular Functional and Imaging Studies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The extracellular matrix molecule brevican is an integral component of the machinery mediating fast synaptic transmission at the calyx of Held.The Journal of physiology · 2015Article
- Nanoscale distribution of presynaptic Ca(2+) channels and its impact on vesicular release during development.Neuron · 2015Article
- Single calcium channel domain gating of synaptic vesicle fusion at fast synapses; analysis by graphic modeling.Channels (Austin, Tex.) · 2015Article
- A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number.The Journal of physiology · 2014Article
- Modulation of synaptic depression of the calyx of Held synapse by GABA(B) receptors and spontaneous activity.The Journal of physiology · 2013Article
- Activity-mediated AMPA receptor remodeling, driven by alternative splicing in the ligand-binding domain.Neuron · 2012Article
- An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Mechanisms underlying signal filtering at a multisynapse contact.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paired-pulse facilitation (PPF) and depression (PPD) are forms of short-term plasticity that are generally thought to reflect changes in transmitter release probability. However, desensitization of postsynaptic AMPA receptors (AMPARs) significantly contributes to PPD at many glutamatergic synapses. To clarify the involvement of AMPAR desensitization in synaptic PPD, we compared PPD with AMPAR desensitization, induced by paired-pulse glutamate application in patches excised from postsynaptic cells at the calyx of Held synapse of developing rats. We found that AMPAR desensitization contributed significantly to PPD before the onset of hearing (P10-12), but that its contribution became negligible after hearing onset. During postnatal development (P7-21) the recovery of AMPARs from desensitization became faster. Concomitantly, glutamate sensitivity of AMPAR desensitization declined. Single-cell reverse transcription-polymerase chain reaction (RT-PCR) analysis indicated a developmental decline of GluR1 expression that correlated with speeding of the recovery of AMPARs from desensitization. Transmitter release probability declined during the second postnatal week (P7-14). Manipulation of the extracellular Ca2+/Mg2+ ratio, to match release probability at P7-8 and P13-15 synapses, revealed that the release probability is also an important factor determining the involvement of AMPAR desensitization in PPD. We conclude that the extent of involvement of AMPAR desensitization in short-term synaptic depression is determined by both pre- and postsynaptic mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.