ArticleThe Journal of physiology2008
Emergence of brain-derived neurotrophic factor-induced postsynaptic potentiation of NMDA currents during the postnatal maturation of the Kolliker-Fuse nucleus of rat.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- The Influence of Neurotrophins on the Brain-Lung Axis: Conception, Pregnancy, and Neonatal Period.Current issues in molecular biology · 2024Review
- Neurochemistry of the Kölliker-Fuse nucleus from a respiratory perspective.Journal of neurochemistry · 2021Review
- The Kölliker-Fuse nucleus: a review of animal studies and the implications for cranial nerve function in humans.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Review
- Developmental changes in the morphology of mouse hypoglossal motor neurons.Brain structure & function · 2016Article
- Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex.The international journal of neuropsychopharmacology · 2014Article
- Learning to breathe: habituation of Hering-Breuer inflation reflex emerges with postnatal brainstem maturation.Respiratory physiology & neurobiology · 2014Article
- Decreased Hering-Breuer input-output entrainment in a mouse model of Rett syndrome.Frontiers in neural circuits · 2013Article
- Pontine mechanisms of respiratory control.Comprehensive Physiology · 2012Review
- A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Postnatal development of N-methyl-D-aspartate receptor subunits 2A, 2B, 2C, 2D, and 3B immunoreactivity in brain stem respiratory nuclei of the rat.Neuroscience · 2010Article
- Exogenous brain-derived neurotrophic factor rescues synaptic dysfunction in Mecp2-null mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Learning to breathe: control of the inspiratory-expiratory phase transition shifts from sensory- to central-dominated during postnatal development in rats.The Journal of physiology · 2009Article
- Pontine respiratory activity involved in inspiratory/expiratory phase transition.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- Breathing disorders in Rett syndrome: progressive neurochemical dysfunction in the respiratory network after birth.Respiratory physiology & neurobiology · 2009Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Kölliker-Fuse nucleus (KF) contributes essentially to respiratory pattern formation and adaptation of breathing to afferent information. Systems physiology suggests that these KF functions depend on NMDA receptors (NMDA-R). Recent investigations revealed postnatal changes in the modulation of glutamatergic neurotransmission by brain-derived neurotrophic factor (BDNF) in the KF. Therefore, we investigated postnatal changes in NMDA-R subunit composition and postsynaptic modulation of NMDA-R-mediated currents by BDNF in KF slice preparations derived from three age groups (neonatal: postnatal day (P) 1-5; intermediate: P6-13; juvenile: P14-21). Immunohistochemistry showed a developmental up-regulation of the NR2D subunit. This correlated with a developmental increase in decay time of NMDA currents and a decline of desensitization in response to repetitive exogenous NMDA applications. Thus, developmental up-regulation of the NR2D subunit, which reduces the Mg(2+) block of NMDA-R, causes these specific changes in NMDA current characteristics. This may determine the NMDA-R-dependent function of the mature KF in the control of respiratory phase transition. Subsequent experiments revealed that bath-application of BDNF progressively potentiated these repetitively evoked NMDA currents only in intermediate and juvenile age groups. Pharmacological inhibition of protein kinase C (PKC), as a downstream component of the BDNF-tyrosine kinase B receptor (trkB) signalling, prevented BDNF-induced potentiation of NMDA currents. BDNF-induced potentiation of NMDA currents in later developmental stages might be essential for synaptic plasticity during the adaptation of the breathing pattern in response to peripheral/central commands. The lack of plasticity in neonatal neurones strengthens the hypothesis that the respiratory network becomes permissive for activity-dependent plasticity with ongoing postnatal development.
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