ArticleThe Journal of physiology2008
The contribution of intrapulmonary shunts to the alveolar-to-arterial oxygen difference during exercise is very small.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Hypoxia and exercise increase the transpulmonary passage of 99mTc-labeled albumin particles in humans.PloS one · 2014Trial
- On the mechanisms that limit oxygen uptake during exercise in acute and chronic hypoxia: role of muscle mass.The Journal of physiology · 2009Trial
- Intrapulmonary arteriovenous anastomoses in healthy dogs assessed using saline contrast echocardiography and response to oxygen therapy.Journal of veterinary internal medicine · 2026Article
- Control of hyperpnoea and pulmonary gas exchange during prolonged exercise: The role of group III/IV muscle afferent feedback.The Journal of physiology · 2024Article
- Intra-pulmonary arteriovenous anastomoses and pulmonary gas exchange: evaluation by microspheres, contrast echocardiography and inert gas elimination.The Journal of physiology · 2019Article
- The Impact of Hyperoxia on Human Performance and Recovery.Sports medicine (Auckland, N.Z.) · 2017Review
- Intrapulmonary arteriovenous anastomoses in humans--response to exercise and the environment.The Journal of physiology · 2015Review
- Maximal oxygen consumption in healthy humans: theories and facts.European journal of applied physiology · 2014Review
- Exercise-Induced Intrapulmonary Arteriovenous Shunt in a Patient Complaining of Dyspnea during Strenuous Exercise.Journal of cardiovascular ultrasound · 2014Article
- Patent foramen ovale is not associated with hypoxemia in severe chronic obstructive pulmonary disease and does not impair exercise performance.American journal of respiratory and critical care medicine · 2014Article
- Pulmonary gas exchange and acid-base balance during exercise.Comprehensive Physiology · 2013Review
- Pulmonary vascular distensibility predicts aerobic capacity in healthy individuals.The Journal of physiology · 2012Article
- Counterpoint: Exercise-induced intrapulmonary shunting is real.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
- Last Word on Point:Counterpoint: Exercise-induced intrapulmonary shunting is imaginary vs. real.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
- Point: Exercise-induced intrapulmonary shunting is imaginary.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
- Transpulmonary passage of 99mTc macroaggregated albumin in healthy humans at rest and during maximal exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
- Contribution of respiratory muscle blood flow to exercise-induced diaphragmatic fatigue in trained cyclists.The Journal of physiology · 2008Article
- Hyperoxia prevents exercise-induced intrapulmonary arteriovenous shunt in healthy humans.The Journal of physiology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Exercise is well known to cause arterial PO2 to fall and the alveolar-arterial PO2 difference(Aa PO2 ) to increase. Until recently, the physiological basis for this was considered to be mostly ventilation/perfusion ((.)VA/(.)Q) inequality and alveolar-capillary diffusion limitation. Recently, arterio-venous shunting through dilated pulmonary blood vessels has been proposed to explain a significant part of the Aa PO2 during exercise. To test this hypothesis we determined venous admixture during 5 min of near-maximal, constant-load, exercise in hypoxia (in inspired O2 fraction, FIO2 , 0.13), normoxia (FIO2 , 0.21) and hyperoxia (FIO2 , 1.0) undertaken in balanced order on the same day in seven fit cyclists ((.)VO2max, 61.3 +/- 2.4 ml kg(-1) min(-1); mean +/- S.E.M.). Venous admixture reflects three causes of hypoxaemia combined: true shunt, diffusion limitation and ((.)VA/(.)Q) inequality. In hypoxia, venous admixture was 22.8 +/- 2.5% of the cardiac output; in normoxia it was 3.5 +/- 0.5%; in hyperoxia it was 0.5 +/- 0.2%. Since only true shunt accounts for venous admixture while breathing 100% O2, the present study suggests that shunt accounts for only a very small portion of the observed venous admixture, Aa PO2 and hypoxaemia during heavy exercise.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.