Evidence map›Paper›PMID 18339655›Full record

ArticleSchizophrenia bulletin2009

Better outcome of schizophrenia in India: a natural selection against severe forms?

Jagadisha Thirthalli, Sanjeev Jain

Abstract read
In one paragraph

Article in Schizophrenia bulletin, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. The census of India and the mentally ill.Indian journal of psychiatry · 2012
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jagadisha ThirthalliNational Institute of Mental Health and Neurosciences, Bangalore, India.
Sanjeev Jain

Funding

International Research Training in Clinical SciencesD43TW005811 · FIC · WASHINGTON UNIVERSITY · PI COTTLER, LINDA B. · 2001 to 2010
$1.8M
FIC NIH HHS 1 D43 TW05811-01FIC NIH HHS D43 TW005811Wellcome Trust
6 · The paper itself

Abstract

Regional variations are observed in outcome of schizophrenia, but reasons remain unclear. Outcome of schizophrenia is reported to be better in India. In this report based on census data, we highlight substantially greater mortality observed among the mentally ill than among the general population during famines in India in the 19th century. A possible selection against the most severe forms of schizophrenia could account for greater occurrence of better-outcome phenotypes. Population histories and environmental influences, including epigenetics, need to be considered to further investigate differences between schizophrenia phenotypes.

Indexed as

Developing CountriesSelection, GeneticCensusesCross-Sectional StudiesEpigenesis, GeneticHumansIndiaOutcome Assessment, Health CarePhenotypeSchizophreniaSocial EnvironmentStarvation

Identifiers

PMID18339655
PMCPMC2669572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.