ArticleBiochemical and biophysical research communications2008
Regulation of pancreatic duct cell differentiation by phosphatidylinositol-3 kinase.
Article in Biochemical and biophysical research communications, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- The key regulation of LncRNA MALAT during reprogramming of primary mouse hepatocytes into insulin producing cells.Scientific reports · 2025Article
- Efficient improvement of the proliferation, differentiation, and anti-arthritic capacity of mesenchymal stem cells by simply culturing on the immobilized FGF2 derived peptide, 44-ERGVVSIKGV-53.Journal of advanced research · 2024Article
- Effect of the PI3K/AKT signaling pathway on hypoxia-induced proliferation and differentiation of bone marrow-derived mesenchymal stem cells.Experimental and therapeutic medicine · 2017Article
- Metformin Restrains Pancreatic Duodenal Homeobox-1 (PDX-1) Function by Inhibiting ERK Signaling in Pancreatic Ductal Adenocarcinoma.Current molecular medicine · 2016Article
- Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation.Genes & development · 2015Article
- Disruption of prostate epithelial differentiation pathways and prostate cancer development.Frontiers in oncology · 2013Review
- Article
- Negative regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Age-dependent reduction of the PI3K regulatory subunit p85α suppresses pancreatic acinar cell proliferation.Aging cell · 2012Article
- FTY720 normalizes hyperglycemia by stimulating β-cell in vivo regeneration in db/db mice through regulation of cyclin D3 and p57(KIP2).The Journal of biological chemistry · 2012Article
- Growth factor control of pancreatic islet regeneration and function.Pediatric diabetes · 2009Review
- Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation.PloS one · 2009Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have previously demonstrated that the phosphatidylinositol-3 kinase (PI3K)/Akt signaling is essential for pancreatic regeneration after partial pancreatectomy in mice. In the present study, we examined a role of PI3K/Akt signaling for pancreatic duct cell differentiation into insulin-producing cells. Epithelial-like cells were isolated from mouse pancreas and confirmed to be positive for a duct cell marker cytokeratin-20 (CK-20) but negative for insulin. Incubation of these cells with epidermal growth factor, exhibited a gradual increase in Akt phosphorylation and expression of pancreatic duodenal homeobox-1 (PDX-1), a regulator of beta-cell differentiation. Three weeks later, these CK-20-positive cells were noted to express insulin as determined by immunofluorescent double-staining. Akt phosphorylation, PDX-1 expression, and insulin production were effectively reduced by blocking the PI3K/Akt pathway using siRNA to the p85alpha regulatory subunit of PI3K. Our results demonstrate that PI3K/Akt activation has a critical role for pancreatic duct cell differentiation into insulin-producing cells.
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