ArticleMolecular cancer2008
Reduction of human chorionic gonadotropin beta subunit expression by modified U1 snRNA caused apoptosis in cervical cancer cells.
Article in Molecular cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- LK-1: an investigational therapy targeting hCG-β in metastatic breast, bladder, ovarian, and cervical cancers.Scientific reports · 2026Article
- Ectopic β-HCG production in a young patient with highly aggressive metastatic lung adenocarcinoma: A rare paraneoplastic manifestation.Respiratory medicine case reports · 2026Article
- HDAC1 Promotes Mitochondrial Pathway Apoptosis and Inhibits the Endoplasmic Reticulum Stress Response in High Glucose-Treated Schwann Cells via Decreased U4 Spliceosomal RNA.Neurochemical research · 2024Article
- Tumor educated platelet: the novel BioSource for cancer detection.Cancer cell international · 2023Review
- The Breast Cancer Protooncogenes HER2, BRCA1 and BRCA2 and Their Regulation by the iNOS/NOS2 Axis.Antioxidants (Basel, Switzerland) · 2022Review
- Comprehensive analysis of molecular mechanism and a novel prognostic signature based on small nuclear RNA biomarkers in gastric cancer patients.Open medicine (Warsaw, Poland) · 2022Article
- Effects of Induced Exosomes from Endometrial Cancer Cells on Tumor Activity in the Presence ofMolecules (Basel, Switzerland) · 2021Article
- Unconventional Actions of Glycoprotein Hormone Subunits: A Comprehensive Review.Frontiers in endocrinology · 2021Review
- Regulation of human chorionic gonadotropin beta subunit expression in ovarian cancer.BMC cancer · 2019Article
- Investigation of factors influencing the immunogenicity of hCG as a potential cancer vaccine.Clinical and experimental immunology · 2018Article
- BRCA1 regulation on β-hCG: a mechanism for tumorigenicity in BRCA1 defective breast cancer.Oncogenesis · 2017Article
- Human Chorionic Gonadotropin and Breast Cancer.International journal of molecular sciences · 2017Review
- CGB activates ERK and AKT kinases in cancer cells via LHCGR-independent mechanism.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Transgenesis-mediated reproductive dysfunction and tumorigenesis: effects of immunological neutralization.PloS one · 2012Article
- Article
- Overexpression of the β subunit of human chorionic gonadotropin promotes the transformation of human ovarian epithelial cells and ovarian tumorigenesis.The American journal of pathology · 2011Article
- CGB and GNRH1 expression analysis as a method of tumor cells metastatic spread detection in patients with gynecological malignances.Journal of translational medicine · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundSecretion of human chorionic gonadotropin, especially its beta subunit by malignant trophoblastic tumors and varieties of tumors of different origin is now well documented; however the role of hCG in tumorogenesis is still unknown.
resultsThis study documents the molecular presence of human chorionic gonadotropin beta subunit in uterine cervix cancer tissues and investigates a novel technique to reduce hCGbeta levels based on expression of a modified U1 snRNA as a method to study the hormone's role in biology of human cervical cancer cells cultured in vitro. The property of U1 snRNA to block the accumulation of specific RNA transcript when it binds to its donor sequence within the 3' terminal exon was used. The first 10 nucleotides of the human U1 snRNA gene, which normally binds to the 5'ss in pre-mRNA were replaced by a sequence complementary to a 10-nt segment in the terminal exon of the hCGbeta mRNA. Three different 5' end-mutated U1 snRNA expression plasmids were tested, each targeting a different sequence in the hCGbeta mRNA, and we found each one blocked the expression of hCGbeta in HeLa cells, a cervix carcinoma cell line, as shown by immunohistochemistry and qRT-PCR. Reduction of hCGbeta levels resulted in a significantly increased apoptosis rate with almost 90% of cells transfected with modified anti-hCGbeta U1 snRNAs showing morphological changes characteristic of the apoptotic process.
conclusionThese data suggest that human chorionic gonadotropin beta subunit may act as a tumor growth-stimulating factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.