ArticleCritical care (London, England)2008
Vasopressin and epinephrine in the treatment of cardiac arrest: an experimental study.
Article in Critical care (London, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 29 citations in OpenAlex.
- The use of epinephrine in out-of-hospital cardiac arres : A retrospective study of the effects of administration timing and cumulative doses on outcome in a physician-staffed emergency medical service system.BMC emergency medicine · 2025Article
- Dose-response study of prophylactic nitroglycerin for prevention of pituitrin-induced hypertension during laparoscopic myomectomy: a prospective, randomized study.Frontiers in medicine · 2023Article
- Fluorescence Sensing Platforms for Epinephrine Detection Based on Low Temperature Cofired Ceramics.Sensors (Basel, Switzerland) · 2020Article
- A Fluorescent Biosensors for Detection Vital Body Fluids' Agents.Sensors (Basel, Switzerland) · 2018Review
- Resuscitation after cardiac arrest in a septic porcine model: adding vasopressin vs epinephrine alone administration.BMC research notes · 2014Article
- Terlipressin versus adrenaline in an infant animal model of asphyxial cardiac arrest.Intensive care medicine · 2010Article
- Optimal vasopressor drug therapy during resuscitation.Critical care (London, England) · 2008Article
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpinephrine remains the drug of choice for cardiopulmonary resuscitation. The aim of the present study is to assess whether the combination of vasopressin and epinephrine, given their different mechanisms of action, provides better results than epinephrine alone in cardiopulmonary resuscitation.
methodsVentricular fibrillation was induced in 22 Landrace/Large-White piglets, which were left untreated for 8 minutes before attempted resuscitation with precordial compression, mechanical ventilation and electrical defibrillation. Animals were randomized into 2 groups during cardiopulmonary resuscitation: 11 animals who received saline as placebo (20 ml dilution, bolus) + epinephrine (0.02 mg/kg) (Epi group); and 11 animals who received vasopressin (0.4 IU/kg/20 ml dilution, bolus) + epinephrine (0.02 mg/kg) (Vaso-Epi group). Electrical defibrillation was attempted after 10 minutes of ventricular fibrillation.
resultsTen of 11 animals in the Vaso-Epi group restored spontaneous circulation in comparison to only 4 of 11 in the Epi group (p = 0.02). Aortic diastolic pressure, as well as, coronary perfusion pressure were significantly increased (p < 0.05) during cardiopulmonary resuscitation in the Vaso-Epi group.
conclusionThe administration of vasopressin in combination with epinephrine during cardiopulmonary resuscitation results in a drastic improvement in the hemodynamic parameters necessary for the return of spontaneous circulation.
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