ArticleCardiovascular diabetology2008
Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample.
Article in Cardiovascular diabetology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 6 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 6 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Pooled it
- Common genetic variation in obesity, lipid transfer genes and risk of Metabolic Syndrome: Results from IDEFICS/I.Family study and meta-analysis.Scientific reports · 2020Pooled it
- Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis.Diabetologia · 2012Pooled it
- Common variant (rs9939609) in the FTO gene is associated with metabolic syndrome.Molecular biology reports · 2012Pooled it
- Genetic variants in FTO associated with metabolic syndrome: a meta- and gene-based analysis.Molecular biology reports · 2012Pooled it
- Pooled it
- Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program.Diabetologia · 2008Trial
- The Gut-Brain Axis in Metabolic Syndrome: Emerging Mechanisms and Perspectives in Personalized Medicine.International journal of molecular sciences · 2026Review
- Gender-specific associations among neck circumference, the rs9939609 FTO gene polymorphism, and the 14-year risk of metabolic syndrome in the Korean adult population.Epidemiology and health · 2024Article
- Precision medicine and metabolic syndrome.ARYA atherosclerosis · 2022Review
- The association of dietary and plasma fatty acid composition with FTO gene expression in human visceral and subcutaneous adipose tissues.European journal of nutrition · 2021Article
- Association between theNutrients · 2021Article
- Ancestry specific associations of FTO gene variant and metabolic syndrome: A longitudinal ARIC study.Medicine · 2020Observational
- Common Polymorphisms Linked to Obesity and Cardiovascular Disease in Europeans and Asians are Associated with Type 2 Diabetes in Mexican Mestizos.Medicina (Kaunas, Lithuania) · 2019Article
- FTO rs9939609 A allele influences anthropometric outcome in response to dietary intervention, but not in response to physical exercise program.European journal of nutrition · 2019Article
- RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases.Frontiers in cardiovascular medicine · 2019Review
- Biochemistry, hormones and adipocytokines in prepubertal children born with IUGR evoke metabolic, hepatic and renal derangements.Scientific reports · 2018Article
- Searching for Factors Raising the Incidence of Metabolic Syndrome Among 45-60-Year-Old Women.Aging and disease · 2018Article
- The (FTO) gene polymorphism is associated with metabolic syndrome risk in Egyptian females: a case- control study.BMC medical genetics · 2017Article
- Maternal and neonatal FTO rs9939609 polymorphism affect insulin sensitivity markers and lipoprotein profile at birth in appropriate-for-gestational-age term neonates.Journal of physiology and biochemistry · 2016Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe rs9939609 T>A single-nucleotide polymorphism (SNP) in the FTO gene has previously been found to be associated with obesity in European Caucasian samples. The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in non-Caucasian samples.
methodsThe FTO rs9939609 SNP was genotyped in 2121 subjects from four different non-Caucasian geographical ancestries. Subjects were classified for the presence or absence of MetS according to the International Diabetes Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel (NCEP ATP) III definitions.
resultsCarriers of > or = 1 copy of the rs9939609 A allele were significantly more likely to have IDF-defined MetS (35.8%) than non-carriers (31.2%), corresponding to a carrier odds ratio (OR) of 1.23 (95% confidence interval [CI] 1.01 to 1.50), with a similar trend for the NCEP ATP III-defined MetS. Subgroup analysis showed that the association was particularly strong in men. The association was related to a higher proportion of rs9939609 A allele carriers meeting the waist circumference criterion; a higher proportion also met the HDL cholesterol criterion compared with wild-type homozygotes.
conclusionThus, the FTO rs9939609 SNP was associated with an increased risk for MetS in this multi-ethnic sample, confirming that the association extends to non-Caucasian population samples.
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