ReviewJournal of cellular physiology2008
The role of viral and bacterial pathogens in gastrointestinal cancer.
Review in Journal of cellular physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of the Gut Microbiome in Clinical Outcomes of Colorectal Cancer: A Systematic Review (2020-2025).Oncology research · 2026Pooled it
- New Evidence forPharmaceuticals (Basel, Switzerland) · 2025Article
- Identification of Gut Microbiota Profile Associated with Colorectal Cancer in Saudi Population.Cancers · 2023Article
- Colorectal Cancer Archaeome: A Metagenomic Exploration, Tunisia.Current issues in molecular biology · 2023Article
- The complexity of human papilloma virus in cancers: a narrative review.Infectious agents and cancer · 2023Review
- Colorectal cancer and gut viruses: a visualized analysis based on CiteSpace knowledge graph.Frontiers in microbiology · 2023Article
- Viruses in colorectal cancer.Molecular oncology · 2022Review
- Cost-effective low-coverage whole-genome sequencing assay for the risk stratification of gastric cancer.World journal of gastrointestinal oncology · 2022Article
- The immunosuppressive microenvironment and immunotherapy in human glioblastoma.Frontiers in immunology · 2022Review
- The Role and Interactions of Programmed Cell Death 4 and its Regulation by microRNA in Transformed Cells of the Gastrointestinal Tract.Frontiers in oncology · 2022Review
- Role of Microbial Infection-Induced Inflammation in the Development of Gastrointestinal Cancers.Medicines (Basel, Switzerland) · 2021Review
- Deep Ultraviolet Light-Emitting Diode Light Therapy forMicroorganisms · 2021Article
- Metagenomic Analyses Expand Bacterial and Functional Profiling Biomarkers for Colorectal Cancer in a Hainan Cohort, China.Current microbiology · 2021Article
- Glioma and temozolomide induced alterations in gut microbiome.Scientific reports · 2020Article
- Review
- No Evidence for an Association between JC Polyomavirus Infection and Gastroduodenal Diseases.Gastrointestinal tumors · 2018Article
- Causal role of infectious agents in cancer: An overview.Caspian journal of internal medicine · 2017Review
- Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.Nature communications · 2014Article
- Pathogenesis of intestinal Pseudomonas aeruginosa infection in patients with cancer.Frontiers in cellular and infection microbiology · 2014Review
- Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The association of Helicobacter pylori (H. pylori) with gastric cancer is thus far the best understood model to comprehend the causal relationship between a microbial pathogen and cancer in the human gastrointestinal tract. Besides H. pylori, a variety of other pathogens are now being recognized as potential carcinogens in different settings of human cancer. In this context, viral causes of human cancers are central to the issue since these account for 10-20% of cancers worldwide. In the case of H. pylori and gastric cancer, as well as the human papillomavirus and anal cancer, the causal relationship between the infectious agent and the related cancer in the gastrointestinal tract has been clearly confirmed by epidemiological and experimental studies. Similarly, Epstein-Barr virus and the oncogenic JC virus are being suggested as possible causative agents for cancers in the upper and lower gastrointestinal tract. This review discusses various viral and microbial pathogens and their oncogenic properties in the evolution of gastrointestinal carcinogenesis and summarizes the available experimental data make a convincing agreement favoring the associations between infectious agents and specific human cancers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.