ArticleJournal of molecular neuroscience : MN2008
Increased GABA B receptor subtype expression in the nucleus of the solitary tract of the spontaneously hypertensive rat.
Article in Journal of molecular neuroscience : MN, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Electroacupuncture Improves Baroreflex andNeural plasticity · 2018Article
- Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia.Clinical science (London, England : 1979) · 2016Review
- The nucleus of the solitary tract and the coordination of respiratory and sympathetic activities.Frontiers in physiology · 2014Review
- GABA(B) Mediated Regulation of Sympathetic Preganglionic Neurons: Pre- and Postsynaptic Sites of Action.Frontiers in neurology · 2010Article
- Angiotensin II enhances GABA(B) receptor-mediated responses and expression in nucleus tractus solitarii of rats.American journal of physiology. Heart and circulatory physiology · 2009Article
- Tonic GABAergic inhibition of sympathetic preganglionic neurons: a novel substrate for sympathetic control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
Expression of GABA(B) receptor messenger RNA (mRNA) in the central nervous system was compared between the spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rat. Polymerase chain reaction (PCR) revealed all the isoforms except B1e in cortex, hypothalamus, and medulla oblongata. In the nucleus of the solitary tract (NTS) and ventrolateral medulla (VLM), the B1a-c and 1 g isoforms were present as well as B2. Real-time PCR detected significantly higher levels of B1a (p < 0.01) and B2 (p < 0.05) mRNA in the NTS of SHR compared to WKY. A significant increase in B1a expression (p < 0.05) was detected in VLM. Immunolabeling suggested presynaptic and postsynaptic expression of B1a, B1b, and B2 subtypes throughout the NTS, with significant differences in distribution patterns and labeling between subtypes and between SHR and WKY. These findings suggest that GABA(B) receptors expressed by neurones in NTS may be involved in cardiovascular regulation and that changes in GABA(B) mRNA expression levels may contribute to the hypertensive state in SHR.
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