ReviewDigestive diseases and sciences2008
Reactive oxygen species and the hypomotility of the gall bladder as targets for the treatment of gallstones with melatonin: a review.
Review in Digestive diseases and sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bidirectional associations among gallstone disease, non-alcoholic fatty liver disease, kidney stone disease.World journal of gastroenterology · 2024Pooled it
- Immunometabolic crosstalk in gallstone disease: driving roles of bacterial infection, NETs and MMP activation.Molecular biology reports · 2026Review
- Association between weekly sleep duration and gallstones in a US-based adult sample: A cross-sectional study.Medicine · 2025Article
- Melatonin and Inflammatory Cytokines as Modulators of the Interaction Between Gestational Diabetes Mellitus and Pregnancy-Specific Urinary Incontinence.Metabolites · 2025Article
- Melatonin's anti-inflammatory and antioxidant effects in gallstone disease: A narrative review.World journal of hepatology · 2025Review
- The roles of lifestyle factors and genetic risk in the association between night shift work and cholelithiasis: a prospective cohort study.Frontiers in endocrinology · 2025Article
- Non-linear association of cardiometabolic index with gallstone disease in US adults: A cross-sectional study.PloS one · 2025Article
- Association between oxidative balance score and gallstone in US adults: a cross-sectional study.Frontiers in aging · 2025Article
- Association between weekend catch-up sleep and gallstone disease in US adults: a cross-sectional study from NHANES 2017-2020.Frontiers in public health · 2025Article
- Insights from exploring the interrelated dynamics of gallstone disease, non-alcoholic fatty liver disease, and kidney stone disease.World journal of gastroenterology · 2024Article
- Association between sleep and gallstone disease in United States adults: A cross-sectional study.BMC public health · 2024Article
- Melatonin Protects the Histologic Structure of the Uterus in Conditions of Zearalenone Intake.Materia socio-medica · 2022Article
- Melatonin and Pathological Cell Interactions: Mitochondrial Glucose Processing in Cancer Cells.International journal of molecular sciences · 2021Review
- Association between Hashimoto's thyroiditis and cholelithiasis: a retrospective cohort study in Taiwan.BMJ open · 2018Article
- Gallstones.Nigerian journal of surgery : official publication of the Nigerian Surgical Research Society · 2013Review
- Molecular mechanisms involved in the protective effect of the chloroform extract of Selaginella lepidophylla (Hook. et Grev.) Spring in a lithiasic rat model.Urolithiasis · 2013Article
- Concept of the pathogenesis and treatment of cholelithiasis.World journal of hepatology · 2012Article
- Role of melatonin in metabolic regulation.Reviews in endocrine & metabolic disorders · 2009Review
- Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.BMC medical genomics · 2009Article
- Evaluation of paraoxonase, malondialdehyde, and lipoprotein levels in patients with asymptomatic cholelithiasis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Free radical-mediated damage of the gall bladder epithelium predisposes to the development of both gall bladder inflammation and gallstone formation, which often coexist. Melatonin, a pineal and gut secretory product, due to its antioxidant activity along with its effect on the aging gall bladder myocytes, inhibits gallstone formation. Melatonin reduces the biliary levels of cholesterol by inhibiting cholesterol absorption across the intestinal epithelium and by increasing the conversion of cholesterol to bile acids. The incidence of gallstones is increasing and is expected to rise dramatically with the increase in the longevity and the risk factors such as obesity. The change in the prevalence of cholelithiasis is associated with a proportionate rise in the incidence of cholangiocarcinoma. In an attempt to improve the quality of life of the rapidly increasing aging population, this article reviews up-to-date information on the pathophysiology of the gall bladder function and discusses the development of new therapies with potential good patient compliance and lower cost than the current treatments.
Indexed as
Identifiers
18338264What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.