ArticleLa Radiologia medica2008
Role of perfusion-weighted imaging at 3 Tesla in the assessment of malignancy of cerebral gliomas.
Article in La Radiologia medica, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Discrimination between Glioma Grades II and III Using Dynamic Susceptibility Perfusion MRI: A Meta-Analysis.AJNR. American journal of neuroradiology · 2017Pooled it
- The diagnostic value of high-frequency power-based diffusion-weighted imaging in prediction of neuroepithelial tumour grading.European radiology · 2017Article
- Diagnosis and New Treatment Modalities for Glioblastoma: Do They Improve Patient Survival?Current molecular medicine · 2016Article
- Diagnostic challenges of primary thalamic gliomas-identification of a minimally enhancing neuroradiological subtype with aggressive neuropathology and poor clinical outcome.Clinical neuroradiology · 2014Article
- Recurrent glioblastoma multiforme versus radiation injury: a multiparametric 3-T MR approach.La Radiologia medica · 2014Article
- The role of diffusion and perfusion weighted imaging in the differential diagnosis of cerebral tumors: a review and future perspectives.Cancer imaging : the official publication of the International Cancer Imaging Society · 2014Review
- Low-grade (WHO II) and anaplastic (WHO III) gliomas: differences in morphology and MRI signal intensities.European radiology · 2013Article
- Differentiation between oligodendroglioma genotypes using dynamic susceptibility contrast perfusion-weighted imaging and proton MR spectroscopy.AJNR. American journal of neuroradiology · 2013Article
- Multiparametric MRI biomarkers for measuring vascular disrupting effect on cancer.World journal of radiology · 2011Article
- 3 T magnetic resonance imaging of the musculoskeletal system.La Radiologia medica · 2010Article
- Imaging of adult astrocytic brain tumours with 7 T MRI: preliminary results.European radiology · 2010Article
- Glioma recurrence versus radiation necrosis: accuracy of current imaging modalities.Journal of neuro-oncology · 2009Review
- Role of advanced MR imaging modalities in diagnosing cerebral gliomas.La Radiologia medica · 2009Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study was performed to clarify the role of perfusion-weighted imaging (PWI) at 3 Tesla in the characterisation of haemodynamic heterogeneity within gliomas and surrounding tissues and in the differentiation of high-grade from low-grade gliomas. MATERIALS AND
methodsWe examined 36 patients with histologically verified gliomas (25 with high-grade and 11 with low-grade gliomas). PWI was performed by first-pass gadopentetate dimeglumine T2*-weighted echo-planar images, and cerebral blood volume (CBV) maps were computed with a nondiffusible tracer model. Relative CBV (rCBV) was calculated by dividing CBV in pathological areas by that in contralateral white matter.
resultsIn high-grade gliomas, rCBV were markedly increased in mass [mean+/-standard deviation (SD), 4.3+/-1.2] and margins (4.0+/-1.1) and reduced in necrotic areas (0.3+/-0.3). Oedematous-appearing areas were divided in two groups according to signal intensity on T2-weighted images: tumour with lower (nearly isointense to grey matter) and oedema with higher (scarcely isointense to cerebrospinal fluid) signal intensity. Tumour showed significantly higher rCBV than did oedema (1.8+/-0.5 vs. 0.5+/-0.2; p<0.001) areas. In low-grade gliomas, mass (2.0+/-1.5) and margin (2.2+/-1.2) rCBV were significantly lower than in high-grade gliomas (p<0.001).
conclusionsThree-Tesla PWI helps to distinguish necrosis from tumour mass, infiltrating tumour from oedema and high-grade from low-grade gliomas. It enhances the magnetic resonance (MR) assessment of cerebral gliomas and provides useful information for planning surgical and radiation treatment.
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