ArticleThe EMBO journal2008
The bacterial flagellar switch complex is getting more complex.
Article in The EMBO journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- CryoEM structures reveal how the bacterial flagellum rotates and switches direction.Nature microbiology · 2024Article
- An evolving view of complex II-noncanonical complexes, megacomplexes, respiration, signaling, and beyond.The Journal of biological chemistry · 2023Review
- Tricarboxylic Acid (TCA) Cycle Enzymes and Intermediates Modulate Intracellular Cyclic di-GMP Levels and the Production of Plant Cell Wall-Degrading Enzymes in Soft Rot PathogenMolecular plant-microbe interactions : MPMI · 2020Article
- A Mechanism of Modulating the Direction of Flagellar Rotation in Bacteria by Fumarate and Fumarate Reductase.Journal of molecular biology · 2019Article
- Protein Activity Sensing in Bacteria in Regulating Metabolism and Motility.Frontiers in microbiology · 2019Review
- Behavioral Variability and Phenotypic Diversity in Bacterial Chemotaxis.Annual review of biophysics · 2018Review
- New crystal forms of the integral membrane Escherichia coli quinol:fumarate reductase suggest that ligands control domain movement.Journal of structural biology · 2018Article
- Crystal structure of an assembly intermediate of respiratory Complex II.Nature communications · 2018Article
- Applying torque to the Escherichia coli flagellar motor using magnetic tweezers.Scientific reports · 2017Article
- Inferring the Chemotactic Strategy of P. putida and E. coli Using Modified Kramers-Moyal Coefficients.PLoS computational biology · 2017Article
- Evidence for Escherichia coli Diguanylate Cyclase DgcZ Interlinking Surface Sensing and Adhesion via Multiple Regulatory Routes.Journal of bacteriology · 2016Article
- CRISPR-Cas gene-editing reveals RsmA and RsmC act through FlhDC to repress the SdhE flavinylation factor and control motility and prodigiosin production in Serratia.Microbiology (Reading, England) · 2016Article
- Binding of the Covalent Flavin Assembly Factor to the Flavoprotein Subunit of Complex II.The Journal of biological chemistry · 2016Article
- Bacterial protein networks: properties and functions.Nature reviews. Microbiology · 2015Review
- Genome-scale identification and characterization of moonlighting proteins.Biology direct · 2014Article
- A minimal model for metabolism-dependent chemotaxis in Rhodobacter sphaeroides (†).Interface focus · 2014Article
- Complete proteome of a quinolone-resistant Salmonella Typhimurium phage type DT104B clinical strain.International journal of molecular sciences · 2014Article
- Article
- Regulation of flagellar motility during biofilm formation.FEMS microbiology reviews · 2013Review
- Energy complexes are apparently associated with the switch-motor complex of bacterial flagella.Journal of molecular biology · 2012Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism of function of the bacterial flagellar switch, which determines the direction of flagellar rotation and is essential for chemotaxis, has remained an enigma for many years. Here we show that the switch complex associates with the membrane-bound respiratory protein fumarate reductase (FRD). We provide evidence that FRD binds to preparations of isolated switch complexes, forms a 1:1 complex with the switch protein FliG, and that this interaction is required for both flagellar assembly and switching the direction of flagellar rotation. We further show that fumarate, known to be a clockwise/switch factor, affects the direction of flagellar rotation through FRD. These results not only uncover a new component important for switching and flagellar assembly, but they also reveal that FRD, an enzyme known to be primarily expressed and functional under anaerobic conditions in Escherichia coli, nonetheless, has important, unexpected functions under aerobic conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.