Trial reportJournal of perinatology : official journal of the California Perinatal Association2008
Maternal-administered physical activity enhances bone mineral acquisition in premature very low birth weight infants.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Physical activity programmes for promoting bone mineralisation and growth in preterm infants.The Cochrane database of systematic reviews · 2026Pooled it
- Effects of Maternal Exercise During Pregnancy on Perinatal Growth and Childhood Obesity Outcomes: A Meta-analysis and Meta-regression.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Physical activity programs for promoting bone mineralization and growth in preterm infants.The Cochrane database of systematic reviews · 2014Pooled it
- Effect of physiotherapy on the promotion of bone mineralization in preterm infants: a randomized controlled trial.Scientific reports · 2022Trial
- Effect of physical therapy on bone remodelling in preterm infants: a multicenter randomized controlled clinical trial.BMC pediatrics · 2022Trial
- Preterm infant weight gain is increased by massage therapy and exercise via different underlying mechanisms.Early human development · 2014Trial
- Thai traditional massage increases biochemical markers of bone formation in postmenopausal women: a randomized crossover trial.BMC complementary and alternative medicine · 2013Trial
- Trial
- Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin-ATF4 Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Interventions for metabolic bone disease of prematurity: A systematic review and meta-analysis.Metabolism open · 2026Article
- Invited Mini Review Metabolic Bone Disease of Prematurity: Overview and Practice Recommendations.Hormone research in paediatrics · 2025Review
- Physical Therapy to Prevent Osteopenia in Preterm Infants: A Systematic Review.Children (Basel, Switzerland) · 2021Review
- Metabolic Bone Disease in Premature Neonates: An Unmet ChallengeJournal of clinical research in pediatric endocrinology · 2020Review
- Breech presentation is associated with lower adolescent tibial bone strength.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- The long-term impact of very preterm birth on adult bone mineral density.Bone reports · 2019Article
- Effect of Early Physical Activity Programs on Motor Performance and Neuromuscular Development in Infants Born Preterm: A Randomized Clinical Trial.Journal of caring sciences · 2017Article
- Positive Social Interactions in a Lifespan Perspective with a Focus on Opioidergic and Oxytocinergic Systems: Implications for Neuroprotection.Current neuropharmacology · 2017Review
- Lower Newborn Bone Mineral Content Associated With Maternal Use of Tenofovir Disoproxil Fumarate During Pregnancy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Article
- Mechanical-tactile stimulation (MTS) intervention in a neonatal stress model improves long-term outcomes on bone.Journal of musculoskeletal & neuronal interactions · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine if physical activity delivered by an infant's mother would be as effective in promoting bone mineral acquisition in preterm very low birth weight (VLBW) infants as the same intervention administered by a trained therapist. PATIENTS AND
methodsPreterm VLBW infants were randomized to receive daily physical activity administered by the infant's mother (MOM, n=11) or a trained therapist (OT, n=11), or control (n=11). Physical activity consisted of range of motion movements against passive resistance to all extremities for 5 to 10 min daily. All infants were fed mother's milk with fortification to 24 kcal oz(-1). Dual energy x-ray of the forearm bone area (BA, cm(2)), mineral content (BMC, g), and density (BMD, g/cm(2)) and measurement of bone formation (bone-specific alkaline phosphatase, BAP) and resorption (urine pyridinium crosslinks of collagen, Pyd) were obtained at study entry and at 2.0 kg of body weight.
resultForearm BA and BMC gains were greater in MOM and OT infants compared to the control infants despite similar postnatal growth rate and nutrient intake. Serum BAP levels decreased in controls but remained unchanged in MOM and OT infants. Urine Pyd levels were similar at baseline to 2.0 kg for all groups. These findings suggest greater bone growth and mineral acquisition in MOM and OT infants than control infants.
conclusionThis study demonstrates that a physical activity program administered by the infant's own mother is as equally effective as therapist-administered physical activity in promoting greater bone growth and mineral acquisition in preterm VLBW infants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.