Evidence map›Paper›PMID 18337584›Full record

ArticleJournal of virology2008

Role for the L1-52/55K protein in the serotype specificity of adenovirus DNA packaging.

Beverly P Wohl, Patrick Hearing

Abstract read
In one paragraph

Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Mysteries of adenovirus packaging.Journal of virology · 2025
    Review
  3. Article
  4. Review
  5. Components of Adenovirus Genome Packaging.Frontiers in microbiology · 2016
    Review
  6. Article
  7. Article
  8. Article
  9. Modification of the early gene enhancer-promoter improves the oncolytic potency of adenovirus 11.Molecular therapy : the journal of the American Society of Gene Therapy · 2012
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Beverly P WohlDepartment of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Patrick Hearing

Funding

ADENOVIRUS AS A VECTOR FOR GENE THERAPYR01AI041636 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI HEARING, PATRICK · 1997 to 2011
$3.6M
NIAID NIH HHS AI041636NIAID NIH HHS R01 AI041636
6 · The paper itself

Abstract

The packaging of adenovirus (Ad) DNA into virions is dependent upon cis-acting sequences and trans-acting proteins. We studied the involvement of Ad packaging proteins in the serotype specificity of packaging. Both Ad5 and Ad17 IVa2 and L4-22K proteins complemented the growth of Ad5 IVa2 and L4-22K mutant viruses, respectively. In contrast, the Ad5 L1-52/55K protein complemented an Ad5 L1-52/55K mutant virus, but the Ad17 L1-52/55K protein did not. The analysis of chimeric proteins demonstrated that the N-terminal half of the Ad5 L1-52/55K protein mediated this function. Finally, we demonstrate that the L4-33K and L4-22K proteins have distinct functions during infection.

Indexed as

AdenoviridaeAmino Acid SequenceCells, CulturedDNA PackagingGene DeletionGenetic Complementation TestHumansMolecular Sequence DataSequence AlignmentSubstrate SpecificityViral ProteinsViral Proteins

Identifiers

PMID18337584
PMCPMC2346739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.