ArticleJournal of virology2008
Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 62 citations in OpenAlex.
- Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk.Immunity & ageing : I & A · 2023Article
- Lymphocyte Landscape after ChronicInternational journal of molecular sciences · 2020Review
- Molecular mechanisms of HBeAg in persistent HBV infection.Hepatology international · 2017Article
- Innate and Adaptive Immune Responses in Chronic HCV Infection.Current drug targets · 2017Review
- Immune and non-immune responses to hepatitis C virus infection.World journal of gastroenterology · 2015Review
- Immune control and failure in HCV infection--tipping the balance.Journal of leukocyte biology · 2014Review
- Adaptive immune response during hepatitis C virus infection.World journal of gastroenterology · 2014Review
- Protective immunity against hepatitis C: many shades of gray.Frontiers in immunology · 2014Review
- Local blockade of epithelial PDL-1 in the airways enhances T cell function and viral clearance during influenza virus infection.Journal of virology · 2013Article
- Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1).Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation.PLoS pathogens · 2010Article
- Adaptive immunity to the hepatitis C virus.Advances in virus research · 2010Review
- Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Adaptive immunity to hepatitis C virus.Viruses · 2009Article
- Association of HIV-specific and total CD8+ T memory phenotypes in subtype C HIV-1 infection with viral set point.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Development of hepatitis C virus vaccines: challenges and progress.Expert review of vaccines · 2009Review
- High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Early interferon therapy for hepatitis C virus infection rescues polyfunctional, long-lived CD8+ memory T cells.Journal of virology · 2008Article
- T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't.Journal of leukocyte biology · 2008Review
- Programmed death-1 expression is associated with the disease status in hepatitis B virus infection.World journal of gastroenterology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
The inhibitory receptor programmed death-1 (PD-1) is present on CD8(+) T cells in chronic hepatitis C virus (HCV), but expression patterns in spontaneously resolving infections are incompletely characterized. Here we report that PD-1 was usually absent on memory CD8(+) T cells from chimpanzees with resolved infections, but sustained low-level expression was sometimes observed in the absence of apparent virus replication. PD-1-positive memory T cells expanded and displayed antiviral activity upon reinfection with HCV, indicating conserved function. This animal model should facilitate studies of whether PD-1 differentially influences effector and memory T-cell function in resolved versus persistent human infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.