Evidence map›Paper›PMID 18337554›Full record

ArticleClinical journal of the American Society of Nephrology : CJASN2008

Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study.

Michael Bennett, Catherine L Dent, Qing Ma, Sudha Dastrala, Frank Grenier, Ryan Workman, Hina Syed, Salman Ali, Jonathan Barasch, Prasad Devarajan

3 registry-linked trialsAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical journal of the American Society of Nephrology : CJASN, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 314 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
314citing papers in PubMed, 6 pooled it
29.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01219998 completednot on this mapstarted 2010, after this paper: background citation

Evaluation of the Predictive Ability of Urinary NGAL as an Early Marker of Acute Kidney Injury Following Cardiac Surgery in Neonates and Infants

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2010 to 2012Enrolled205ConditionsPeritoneal Lesion
NCT01382758 completednot on this mapstarted 2011, after this paper: background citation

Use of Near Infrared Spectroscopy (NIRS) for the Early Detection of Acute Kidney Injury in Children Post Cardiopulmonary Bypass

TypeobservationalSponsorUniversity of Colorado, DenverRan2011 to 2013Enrolled107ConditionsAcute Kidney Injury, Heart, Dysfunction Postoperative, Cardiac Surgery, Children
NCT02276170 terminatednot on this mapstarted 2014, after this paper: background citation

Pharmacology of Aminophylline for Acute Kidney Injury in Neonates

TypeobservationalSponsorStanford UniversityRan2014 to 2018Enrolled9ConditionsAcute Kidney Injury
3 · Its place in the literature

Who cites it

314 citing papers in PubMed, 6 syntheses or guidelines pooled it, 766 citations in OpenAlex.

  1. Pooled it
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  3. Biomarkers of acute kidney injury in pediatric cardiac surgery.Pediatric nephrology (Berlin, Germany) · 2022
    Pooled it
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  5. Guideline
  6. Pooled it
  7. Trial
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  16. A Double-Blinded, Randomized, Placebo-Controlled Clinical Trial of Aminophylline to Prevent Acute Kidney Injury in Children Following Congenital Heart Surgery With Cardiopulmonary Bypass.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2016
    Trial
  17. Pediatric reference ranges for acute kidney injury biomarkers.Pediatric nephrology (Berlin, Germany) · 2015
    Trial
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  20. Article

254 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Michael BennettNephrology & Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH 45229-3039, USA.
Catherine L Dent
Qing Ma
Sudha Dastrala
Frank Grenier
Ryan Workman
Hina Syed
Salman Ali
Jonathan Barasch
Prasad Devarajan
Columbia University · USAbbott (United States) · USUniversity of Cincinnati · USCincinnati Children's Hospital Medical Center · US

Funding

STRUCTURAL AND FUNCTIONAL DEVELOPMENT OF THE KIDNEYP50DK052612 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GOMEZ, ROBERTO ARIEL · 1997 to 2006
$6.8M
ANKYRIN: CRUCIAL LINKER IN RENAL CELL APOPTOTIC CASCADESR01DK053289 · NIDDK · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI DEVARAJAN, PRASAD · 2000 to 2003
$674k
NGAL: A novel early biomarker of acute renal injuryR21DK070163 · NIDDK · CHILDREN'S HOSPITAL MED CTR (CINCINNATI) · PI DEVARAJAN, PRASAD · 2004 to 2005
$410k
NIDDK NIH HHS P50 DK052612NIDDK NIH HHS P50-DK52612NIDDK NIH HHS R01 DK053289NIDDK NIH HHS R01-DK53289NIDDK NIH HHS R21 DK070163NIDDK NIH HHS R21-DK070163
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe authors have previously shown that urine neutrophil gelatinase-associated lipocalin (NGAL), measured by a research ELISA, is an early predictive biomarker of acute kidney injury (AKI) after cardiopulmonary bypass (CPB). In this study, whether an NGAL immunoassay developed for a standardized clinical platform (ARCHITECT analyzer, Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, IL) can predict AKI after CPB was tested. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In a pilot study with 136 urine samples (NGAL range, 0.3 to 815 ng/ml) and 6 calibration standards (NGAL range, 0 to 1000 ng/ml), NGAL measurements by research ELISA and by the ARCHITECT assay were highly correlated (r = 0.99). In a subsequent study, 196 children undergoing CPB were prospectively enrolled and serial urine NGAL measurements obtained by ARCHITECT assay. The primary outcome was AKI, defined as a > or = 50% increase in serum creatinine.

resultsAKI developed in 99 patients (51%), but the diagnosis using serum creatinine was delayed by 2 to 3 d after CPB. In contrast, mean urine NGAL levels increased 15-fold within 2 h and by 25-fold at 4 and 6 h after CPB. For the 2-h urine NGAL measurement, the area under the curve was 0.95, sensitivity was 0.82, and the specificity was 0.90 for prediction of AKI using a cutoff value of 100 ng/ml. The 2-h urine NGAL levels correlated with severity and duration of AKI, length of stay, dialysis requirement, and death.

conclusionsAccurate measurements of urine NGAL are obtained using the ARCHITECT platform. Urine NGAL is an early predictive biomarker of AKI severity after CPB.

Indexed as

Cardiac Surgical ProceduresReagent Kits, DiagnosticAcute Kidney InjuryAcute-Phase ProteinsBiomarkersCalibrationCardiopulmonary BypassChild, PreschoolCreatinineCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoassayLength of StayLipocalin-2Acute-Phase ProteinsBiomarkersCreatinineLCN2 protein, humanLipocalin-2LipocalinsProto-Oncogene ProteinsReagent Kits, Diagnostic

Identifiers

PMID18337554
PMCPMC2386703
OpenAlexW2165088763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.