ArticleProceedings of the National Academy of Sciences of the United States of America2008
Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
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96 citing papers in PubMed, 243 citations in OpenAlex.
- A MAP-SNARE interaction links cortical microtubules to the exocytic fusion machinery during auxin-dependent growth remodeling.Science advances · 2026Article
- Omic characterisation of multi-component defences against the necrotrophic pathogen Pyrenophora tritici-repentis in wheat.Plant biology (Stuttgart, Germany) · 2025Article
- Review
- Gravacin as an inhibitor of the auxin transport-activating protein kinase D6PK inFrontiers in plant science · 2025Article
- New Insights into the Enhancement of Adventitious Root Formation Using N,N'-Bis(2,3-methylenedioxyphenyl)urea.Plants (Basel, Switzerland) · 2023Article
- Regulation of PIN-FORMED Protein Degradation.International journal of molecular sciences · 2023Review
- Endocytic trafficking promotes vacuolar enlargements for fast cell expansion rates in plants.eLife · 2022Article
- Fourteen Stations of Auxin.Cold Spring Harbor perspectives in biology · 2022Review
- Microtubules play a crucial role in regulating actin organization and cell initiation in cotton fibers.Plant cell reports · 2022Article
- The Role of Hydrogen Sulfide in Plant Roots during Development and in Response to Abiotic Stress.International journal of molecular sciences · 2022Review
- Systematic analysis of specific and nonspecific auxin effects on endocytosis and trafficking.Plant physiology · 2021Article
- Chemical Biology in Auxin Research.Cold Spring Harbor perspectives in biology · 2021Review
- The Diverse Salt-Stress Response of ArabidopsisPlants (Basel, Switzerland) · 2021Article
- Naphthylphthalamic acid associates with and inhibits PIN auxin transporters.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A Retro-Perspective on Auxin Transport.Frontiers in plant science · 2021Article
- Bundling up the Role of the Actin Cytoskeleton in Primary Root Growth.Frontiers in plant science · 2021Review
- TheQuantitative plant biology · 2021Review
- Coefficient of variation as an image-intensity metric for cytoskeleton bundling.Scientific reports · 2020Article
- Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants.Science advances · 2020Article
- TDIF peptides regulate root growth by affecting auxin homeostasis and PINs expression in Arabidopsis thaliana.Planta · 2020Article
36 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 12 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many aspects of plant development, including patterning and tropisms, are largely dependent on the asymmetric distribution of the plant signaling molecule auxin. Auxin transport inhibitors (ATIs), which interfere with directional auxin transport, have been essential tools in formulating this concept. However, despite the use of ATIs in plant research for many decades, the mechanism of ATI action has remained largely elusive. Using real-time live-cell microscopy, we show here that prominent ATIs such as 2,3,5-triiodobenzoic acid (TIBA) and 2-(1-pyrenoyl) benzoic acid (PBA) inhibit vesicle trafficking in plant, yeast, and mammalian cells. Effects on micropinocytosis, rab5-labeled endosomal motility at the periphery of HeLa cells and on fibroblast mobility indicate that ATIs influence actin cytoskeleton. Visualization of actin cytoskeleton dynamics in plants, yeast, and mammalian cells show that ATIs stabilize actin. Conversely, stabilizing actin by chemical or genetic means interferes with endocytosis, vesicle motility, auxin transport, and plant development, including auxin transport-dependent processes. Our results show that a class of ATIs act as actin stabilizers and advocate that actin-dependent trafficking of auxin transport components participates in the mechanism of auxin transport. These studies also provide an example of how the common eukaryotic process of actin-based vesicle motility can fulfill a plant-specific physiological role.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.