ArticleProceedings of the National Academy of Sciences of the United States of America2008
Genomic imprinting effects on adult body composition in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 71 citations in OpenAlex.
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- Sexes on the brain: Sex as multiple biological variables in the neuronal control of feeding.Biochimica et biophysica acta. Molecular basis of disease · 2020Review
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- Modification of Experimental Design and Statistical Method for Mapping Imprinted QTLs Based on Immortalized FFrontiers in genetics · 2020Article
- The genetics of morphological and behavioural island traits in deer mice.Proceedings. Biological sciences · 2019Article
- Offspring genes indirectly influence sibling and maternal behavioural strategies over resource share.Proceedings. Biological sciences · 2017Article
- A population level atlas of Mus musculus craniofacial skeleton and automated image-based shape analysis.Journal of anatomy · 2017Article
- Genome-wide random regression analysis for parent-of-origin effects of body composition allometries in mouse.Scientific reports · 2017Article
- Incorporating parent-of-origin effects in whole-genome prediction of complex traits.Genetics, selection, evolution : GSE · 2016Article
- Gene expression profiling of white adipose tissue reveals paternal transmission of proneness to obesity.Scientific reports · 2016Article
- A GWAS assessment of the contribution of genomic imprinting to the variation of body mass index in mice.BMC genomics · 2015Article
- Mapping complex traits as a dynamic system.Physics of life reviews · 2015Review
- An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins.Nature communications · 2014Article
- A model for family-based case-control studies of genetic imprinting and epistasis.Briefings in bioinformatics · 2014Article
- Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup.PLoS biology · 2014Article
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- Body composition and gene expression QTL mapping in mice reveals imprinting and interaction effects.BMC genetics · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Genomic imprinting results in the differential expression of genes, depending on which allele is inherited from the mother and which from the father. The effects of such differential gene expression are reflected in phenotypic differences between the reciprocal heterozygotes (Aa vs. aA). Although many imprinted genes have been identified and play a key role in development, little is known about the contribution of imprinting to quantitative variation in trait expression. Here, we examine this problem by mapping imprinting effects on adult body composition traits in the F(3) generation of an intercross between the Large (LG/J) and Small (SM/J) inbred mouse strains. We identified eight pleiotropic imprinted quantitative trait loci (iQTL) located throughout the genome. Most iQTL are in novel locations that have not previously been associated with imprinting effects, but those on chromosomes 7, 12, and centromeric 18 lie in regions previously identified as containing imprinted genes. Our results show that the effects of genomic imprinting are relatively small, with reciprocal heterozygotes differing by approximately 0.25 standard deviation units and the effects at each locus accounting for 1% to 4% of the phenotypic variance. We detected a variety of imprinting patterns, with paternal expression being the most common. These results indicate that genomic imprinting has small, but detectable, effects on the normal variation of complex traits in adults and is likely to be more common than usually thought.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.